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Computer-Aided Three-Dimensional Visualization in the Treatment of Locally Advanced Thyroid Cancer
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Patterns of structural recurrence in papillary thyroid cancer
Schelto Kruijff1, Japke F Petersen, Paul Chen
1University of Sydney Endocrine Surgery Unit, Royal North Shore Hospital, Suite 202, 69 Christie St., St. Leonards, Sydney, NSW, 2065, Australia, kruijffs@gmail.com.
World Journal of Surgery
|October 24, 2013
Summary
Papillary thyroid carcinoma recurrence often occurs in the lateral neck, not the central compartment. Understanding these patterns aids in managing this challenging aspect of PTC treatment.
Area of Science:
- Oncology
- Surgical Oncology
- Head and Neck Surgery
Background:
- Papillary thyroid carcinoma (PTC) rarely causes mortality but frequently recurs locally.
- Understanding locoregional recurrence patterns is crucial for effective PTC management.
Purpose of the Study:
- To clarify the pattern of structural locoregional recurrence in papillary thyroid carcinoma.
- To identify risk factors associated with PTC recurrence.
Main Methods:
- Retrospective cohort study of 1,183 PTC patients (1980-2013).
- Data from a single tertiary referral center's thyroid cancer database.
- Primary outcome: recurrence requiring reoperation; secondary outcomes: site, time, and risk factors.
Main Results:
- Overall structural recurrence rate was 7.9%, with median reoperation time of 31 months.
- Younger age, male gender, larger tumors, and more positive lymph nodes predicted recurrence.
- Lateral neck compartments (levels I-V) were involved more frequently (67%) than the central compartment (level VI) (32%).
Conclusions:
- The lateral neck is the most common site for structural recurrence in PTC requiring surgery.
- This finding is significant in centers with a liberal approach to central compartment lymph node dissection.
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