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Updated: May 6, 2026
07:01
An Orthotopic Mouse Model of Anaplastic Thyroid Carcinoma
Published on: April 17, 2013
24.0K
Primary amyloid goiter mimicking rapid growing thyroid malignancy.
Kyong Hye Joung1, Jae-Yong Park, Koon Soon Kim
1Department of Internal Medicine, Research Center for Endocrine and Metabolic Diseases, School of Medicine, Chungnam National University, Daejeon, South Korea.
Summary
Localized amyloid goiter, a rare thyroid mass from amyloid accumulation, can mimic malignancy. Prompt diagnosis and surgical removal resolved symptoms in a rapidly growing case, highlighting the need for vigilance.
Area of Science:
- Endocrinology
- Pathology
- Oncology
Background:
- Amyloid goiter is a rare manifestation of primary amyloidosis, involving thyroid gland amyloid accumulation.
- Localized primary amyloid goiter, confined solely to the thyroid, represents an even rarer clinical presentation.
Observation:
- A patient presented with a rapidly enlarging thyroid mass causing dysphagia and exertional dyspnea.
- The clinical presentation mimicked thyroid malignancy, specifically anaplastic carcinoma.
Findings:
- Microscopic examination confirmed a diagnosis of amyloid goiter.
- Surgical intervention led to complete resolution of the patient's symptoms.
Implications:
- Rapidly enlarging thyroid masses with dysphagia or dyspnea warrant consideration of amyloid goiter alongside malignancy.
- Suspicion of amyloid goiter is crucial even in the absence of suspected systemic amyloidosis.
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