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Related Experiment Video

Updated: May 6, 2026

Whole-mount Confocal Microscopy for Adult Ear Skin: A Model System to Study Neuro-vascular Branching Morphogenesis and Immune Cell Distribution
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Animal models of scleroderma: current state and recent development.

Yoshihide Asano1, Shinichi Sato

  • 1Department of Dermatology, University of Tokyo Graduate School of Medicine, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan, yasano-tky@umin.ac.jp.

Current Rheumatology Reports
|October 24, 2013
PubMed
Summary

New animal models for systemic sclerosis (SSc) offer insights into disease mechanisms. These models highlight the roles of reactive oxygen species, angiotensin II, and specific transcription factors in SSc pathology, paving the way for new therapies.

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Area of Science:

  • Rheumatology
  • Immunology
  • Pathology

Background:

  • Systemic sclerosis (SSc) is a complex multisystem disease with immunological abnormalities, vasculopathy, and fibrosis.
  • Existing animal models partially represent SSc, but none fully capture its clinical picture, impeding therapeutic development.

Purpose of the Study:

  • To review recent advancements in SSc animal models.
  • To identify novel therapeutic targets for SSc based on insights from these models.

Main Methods:

  • Review of recent inducible and genetic animal models of SSc.
  • Analysis of pathological processes including fibrosis and vasculopathy.

Main Results:

  • Inducible models highlight the roles of reactive oxygen species, angiotensin II, and DNA topoisomerase I/IL-6 in SSc fibrosis.

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  • Genetic models implicate transcription factors Fra-2 and Fli1 in SSc fibrosis and vasculopathy.

    • Conclusions:

    • New SSc animal models provide crucial insights into disease pathogenesis.
    • These models offer promising therapeutic targets for treating systemic sclerosis.