Multifunctional plasmonic nanorattles for spectrum-guided locoregional therapy
Naveen Gandra1, Christopher Portz, Srikanth Singamaneni
1Department of Mechanical Engineering and Materials Science, Washington University in St. Louis, 318 Jolley Hall, 1 Brookings Drive, St. Louis, MO, 63130, USA.
Abstract:
Locoregional death of cancer cells (in vitro) is induced by ablation of plasmonic nanorattles combined with triggered release of a chemotherapeutic drug from the nanorattles. Completion of the therapy process is indicated by a "Raman signal flip" between the two reporters of the surface-enhanced Raman scattering (SERS) probe. The nanorattles enable targeted delivery of payload and simultaneous monitoring of the payload release and the therapy process.
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