Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Mouse Models of Cancer Study

Mouse Models of Cancer Study

Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Mapping histologic and functional maturation of human endocrine pancreas across early postnatal periods.

Nature communications·2026

Same author

Subtype-specific differences in susceptibility to monoclonal antibodies and vaccines among contemporary RSV-A and RSV-B isolates.

bioRxiv : the preprint server for biology·2026

Same author

Transition from infectivity and immune escape to pure escape as an evolutionary strategy during the COVID-19 pandemic.

bioRxiv : the preprint server for biology·2026

Same author

Crystallized colony-stimulating factor-1 receptor inhibitor protects immunoisolated allo but not xeno transplants in primates.

Science translational medicine·2026

Same author

Increased longevity of circulating human IgG in an NSG Fc gamma receptor-1 deficient humanized mouse model.

Journal of pharmaceutical sciences·2025

Same author

Computationally designed proteins mimic antibody immune evasion in viral evolution.

Immunity·2025

Same journal

NET-inducing ability of Cutibacterium acnes clinical isolates is associated with pathogenicity in acne vulgaris.

The Journal of infectious diseases·2026

Same journal

Optimizing the Use of Proviral DNA HIV Drug Resistance Testing: Clinical Applications and Cautions.

The Journal of infectious diseases·2026

Same journal

Monitoring HLA-A2-restricted T cell responses and BCLA-specific serostatus during human latent Toxoplasma gondii infection suggests the implication of CD8+ T cells in parasite containment.

The Journal of infectious diseases·2026

Same journal

Cryptosporidiosis in Ptients with Inborn Errors of Immunity: Retrospective cohort study of the French National Reference Center (CEREDIH).

The Journal of infectious diseases·2026

Same journal

Type 3 fimbrial regulation underpins anti-MrkA immunotherapeutic efficacy in experimental Klebsiella pneumoniae infection.

The Journal of infectious diseases·2026

Same journal

Rationalising heterogeneity in Staphylococcus aureus bacteraemia: current progress and future goals.

The Journal of infectious diseases·2026

See all related articles

Search research articles

Related Experiment Video

Updated: May 6, 2026

Humanized NOG Mice for Intravaginal HIV Exposure and Treatment of HIV Infection

Humanized NOG Mice for Intravaginal HIV Exposure and Treatment of HIV Infection

Published on: January 31, 2020

Overcoming current limitations in humanized mouse research.

Michael A Brehm¹, Leonard D Shultz, Jeremy Luban

¹Program in Molecular Medicine, University of Massachusetts Medical School, Worcester.

The Journal of Infectious Diseases

|October 24, 2013

Summary

This summary is machine-generated.

Humanized mouse models, engineered with specific genetic mutations, offer powerful preclinical tools for studying human immunity and diseases like HIV. Researchers are developing advanced models to overcome existing limitations for better insights into human immunobiology.

Keywords:

humanized immunobiology infectious disease

More Related Videos

Production of Humanized Mouse via Thymic Renal Capsule Grafting, CD34+ Cells Injection, and Cytokine Delivery

Production of Humanized Mouse via Thymic Renal Capsule Grafting, CD34+ Cells Injection, and Cytokine Delivery

Published on: September 27, 2021

Generation of a Humanized Mouse Liver Using Human Hepatic Stem Cells

Generation of a Humanized Mouse Liver Using Human Hepatic Stem Cells

Published on: August 29, 2016

Related Experiment Videos

Last Updated: May 6, 2026

Humanized NOG Mice for Intravaginal HIV Exposure and Treatment of HIV Infection

Humanized NOG Mice for Intravaginal HIV Exposure and Treatment of HIV Infection

Published on: January 31, 2020

Production of Humanized Mouse via Thymic Renal Capsule Grafting, CD34+ Cells Injection, and Cytokine Delivery

Production of Humanized Mouse via Thymic Renal Capsule Grafting, CD34+ Cells Injection, and Cytokine Delivery

Published on: September 27, 2021

Generation of a Humanized Mouse Liver Using Human Hepatic Stem Cells

Generation of a Humanized Mouse Liver Using Human Hepatic Stem Cells

Published on: August 29, 2016

Area of Science:

Immunology
Preclinical Research

Background:

Humanized mouse models are crucial alternatives to in vitro and nonhuman primate studies for human immunobiology.
A key advancement involved IL2rg(null) mutations in T and B cell-deficient mice, enabling functional human immune system engraftment.
These models are vital for studying human immunity, hematopoiesis, regeneration, cancer, and infectious diseases.

Purpose of the Study:

To provide an overview of emerging humanized mouse models.
To discuss their application in infectious disease research.
To highlight current limitations and ongoing advancements in model development.

Main Methods:

Utilizing immunodeficient mice engrafted with human cells and tissues.
Introducing targeted mutations, such as in the IL-2 receptor common gamma chain (IL2rg(null)).
Analyzing the engrafted human immune system's functionality and limitations.

Main Results:

Humanized mice support the development of functional human immune systems, including specific immune cell types.
These models facilitate the study of human-specific pathogens like HIV-1, EBV, and S. typhi.
Current models exhibit limitations that drive the development of next-generation systems.

Conclusions:

Humanized mice are indispensable for preclinical research in human immunity and disease pathogenesis.
Ongoing research focuses on refining these models to address existing immune defects.
Next-generation humanized mice promise enhanced utility for studying complex human biological processes and diseases.