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Updated: May 6, 2026
Immunoglobulin Gene Sequence Analysis In Chronic Lymphocytic Leukemia: From Patient Material To Sequence Interpretation
Published on: November 26, 2018
Occurrence of chronic lymphocytic leukemia in patients with chronic myelogenous leukemia
1Department of Pathology, Hackensack University Medical Center, Rutgers New Jersey Medical School, New Jersey, USA.
Insights
Chronic lymphocytic leukemia (CLL) is a common adult leukemia. The rare co-occurrence of CLL with chronic myeloid leukemia (CML) is documented, with CML sometimes preceding CLL.
Area of Science:
- Hematology
- Oncology
- Internal Medicine
Background:
- Chronic lymphocytic leukemia (CLL) is the most prevalent leukemia in adults in Western countries, accounting for approximately 33% of all leukemia diagnoses.
- CLL incidence rises with age, predominantly affecting older populations.
- Chronic myeloid leukemia (CML) is a myeloproliferative neoplasm arising from abnormal stem cells, affecting myeloid and sometimes lymphoid lineages.
Purpose of the Study:
- To investigate the rare association between Chronic lymphocytic leukemia (CLL) and myeloid malignancies, specifically Chronic myeloid leukemia (CML).
- To review documented cases of simultaneous or sequential occurrence of CLL and CML in the same patients.
Main Methods:
- Literature review of cases reporting both Chronic lymphocytic leukemia (CLL) and Chronic myeloid leukemia (CML) in the same patient.
- Analysis of the temporal relationship between CLL and CML diagnoses in co-occurring cases.
Main Results:
- The simultaneous or sequential occurrence of Chronic lymphocytic leukemia (CML) and Chronic myeloid leukemia (CML) in the same patient is a rare clinical finding.
- In documented instances, Chronic myeloid leukemia (CML) can either occur concurrently with Chronic lymphocytic leukemia (CLL) or be diagnosed subsequent to it.
Conclusions:
- The co-existence of Chronic lymphocytic leukemia (CLL) and Chronic myeloid leukemia (CML) is infrequent.
- Understanding the presentation patterns of these co-occurring leukemias is important for clinical management.
Abstract:
Chronic lymphocytic leukemia (CLL) is the most common leukemia of adults in the western world and constitutes about 33% of all leukemia's. The incidence of CLL increases with age and are more common in older population. Chronic myeloid leukemia (CML) on the contrary occurs in both young adults and elderly and is a chronic myeloproliferative disease that originates from abnormal pluripotent stem cells and results in involvement of multiple hematopoietic lineages, but predominantly myeloid and less commonly lymphoid. Association between CLL and myeloid malignancies (CML, acute myeloid leukemia and MDS, myelodysplastic syndrome) is rare. In literature documenting CLL and CML in same patients, occur either simultaneously or CML is preceded by CLL.
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