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Role of 30 kDa antigen of enteric bacterial pathogens as a possible arthritogenic factor in post-dysenteric reactive

Malkit Singh1, N K Ganguli, Harminder Singh

  • 1Department of Medical Microbiology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Indian Journal of Pathology & Microbiology
|October 25, 2013
PubMed
Abstract

Insights

A common 30 kDa antigen was identified in enteric bacteria causing reactive arthritis (ReA). This antigen triggers an immune response in ReA patients, suggesting its role as an arthritogenic factor.

Area of Science:

  • Immunology
  • Microbiology
  • Rheumatology

Background:

  • Reactive arthritis (ReA), also known as Reiter's syndrome (RS), can follow infections by enteric bacteria.
  • The precise mechanisms by which different pathogens induce similar ReA symptoms remain unclear.

Purpose of the Study:

  • To investigate the presence and function of a shared bacterial antigen among pathogens isolated from ReA patients.
  • To identify potential common triggers for post-infectious arthritis.

Main Methods:

  • Analysis of 51 ReA patients and 75 controls (including patients with bacillary dysentery and other arthritic conditions).
  • Isolation and testing of enteric pathogens to detect immunodominant antigens.
  • Serological and lymphocyte proliferation assays to assess immune responses to identified antigens.

Main Results:

  • A common 30 kDa antigen was detected in arthritogenic strains of Salmonella, Shigella, and Hafnia.
  • ReA patients exhibited elevated IgG, IgM, and IgA antibody levels against the 30 kDa antigen compared to controls.
  • Lymphocytes from ReA patients showed increased proliferation and IL-2 production in response to this antigen.

Conclusions:

  • The 30 kDa antigen is a potential common arthritogenic factor in post-dysenteric ReA/RS.
  • This study reports the first association of Hafnia alvei with post-dysenteric ReA.
  • Similarities in antigen association between mycobacterial and enteric ReA suggest a shared arthritogenic mechanism.

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