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Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting

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Lemierre's syndrome.

Wesley Eilbert¹, Nitin Singla

¹Department of Emergency Medicine, University of Illinois, College of Medicine, 1819 West Polk Street, Room 471 CME, Chicago, IL 60612, USA. weilbert@uic.edu.

International Journal of Emergency Medicine

|October 25, 2013

Summary

This summary is machine-generated.

Lemierre's syndrome, a rare but serious condition involving internal jugular vein thrombophlebitis and bacteremia, is increasingly reported. Early suspicion in young patients with pharyngitis and subsequent septic symptoms is crucial for timely diagnosis and treatment.

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Area of Science:

Infectious Diseases
Vascular Medicine
Microbiology

Background:

Lemierre's syndrome is characterized by internal jugular vein thrombophlebitis and bacteremia, typically from anaerobic oropharyngeal infections.
While uncommon during the antibiotic era, its incidence has risen in the last 15 years.
It presents a diagnostic challenge, often mimicking other conditions like pneumonia or neck abscesses.

Purpose of the Study:

To review the existing literature on Lemierre's syndrome.
To highlight the increasing frequency of this rare condition.
To present a case study of a child diagnosed with Lemierre's syndrome.

Main Methods:

Literature review of Lemierre's syndrome cases.
Analysis of diagnostic criteria including imaging and blood cultures.
Case report of a pediatric patient.

Main Results:

Lemierre's syndrome diagnosis relies on identifying internal jugular vein thrombophlebitis and anaerobic bacteria in blood cultures.
Prolonged pharyngitis followed by septicemic or pneumonic symptoms, or neck pain, should raise suspicion.
Treatment typically involves extended antibiotic courses, sometimes with anticoagulation.

Conclusions:

Lemierre's syndrome requires high clinical suspicion in specific patient presentations.
Prompt diagnosis and appropriate treatment, including antibiotics and potentially anticoagulation, are essential for favorable outcomes.
Increased awareness and reporting are necessary due to its rising frequency.