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Aptamers as theranostic agents: modifications, serum stability and functionalisation.
Sarah Shigdar1, Joanna Macdonald, Michael O'Connor
1School of Medicine, Deakin University, Pigdons Road, Waurn Ponds, Victoria 3217, Australia. sarah.shigdar@deakin.edu.au.
Aptamers, selected through Systematic Evolution of Ligands by Exponential Enrichment (SELEX), are being modified with new bases. These modifications enhance stability and enable use as diagnostic and therapeutic agents.
Area of Science:
- Biotechnology
- Molecular Biology
- Chemical Biology
Background:
- Aptamers, generated via Systematic Evolution of Ligands by Exponential Enrichment (SELEX), have existed for over two decades.
- SELEX procedures have undergone significant modifications since their inception.
Purpose of the Study:
- To review the use of modified bases in aptamer development.
- To highlight aptamers' potential as therapeutic and diagnostic agents.
Main Methods:
- Discussion of modified bases incorporation into aptamer sequences.
- Review of aptamer functionalization strategies.
Main Results:
- Modified bases enhance aptamer serum stability.
- Functionalized aptamers show promise for diagnostic applications.
Conclusions:
- Aptamer technology continues to evolve with modified bases.
- These advancements facilitate the development of novel therapeutic and diagnostic tools.
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