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Updated: May 6, 2026

Study of In Vivo Glucose Metabolism in High-fat Diet-fed Mice Using Oral Glucose Tolerance Test OGTT and Insulin Tolerance Test ITT
Published on: January 7, 2018
The evolution of non-diabetic hyperglycemia: a longitudinal study
Rie Oka1, Kunimasa Yagi, Kenshi Hayashi
1Department of Internal Medicine, Hokuriku Central Hospital, Toyama, Japan.
Impaired glucose regulation risk factors include reduced beta cell function for impaired fasting glucose and low insulin sensitivity for impaired glucose tolerance. Male gender, high BMI, and family history also contribute to diabetes progression.
Area of Science:
- Endocrinology
- Metabolic Diseases
- Diabetes Research
Background:
- Risk factors for impaired fasting glucose (IFG) and impaired glucose tolerance (IGT) require further elucidation.
- Understanding predisposing factors is crucial for preventing progression to type 2 diabetes.
Purpose of the Study:
- To identify predisposing factors for IFG and IGT in Japanese adults with normal glucose tolerance (NGT).
- To establish predictors for the worsening of glucose tolerance over time.
Main Methods:
- Analysis of 604 Japanese adults with NGT using a 75 g oral glucose tolerance test (OGTT).
- Assessment of glucose-stimulated insulin secretion (GSIS), whole body insulin sensitivity (SI), and beta cell function (BCF) using validated indices.
- Follow-up OGTT after 3.7 years to determine changes in glucose tolerance status.
Main Results:
- Attenuated beta cell function (BCF) from low glucose-stimulated insulin secretion (GSIS) independently predicted IFG.
- Low whole body insulin sensitivity (SI) was an additional risk factor for IGT.
- Male gender, high BMI, and a positive diabetes family history were associated with progression to IFG and/or IGT.
Conclusions:
- Reduced beta cell function and insulin sensitivity are key risk factors for developing IFG and IGT.
- Clinical factors like male gender, high BMI, and family history aid in predicting glucose tolerance worsening.
- These findings support the development of early intervention strategies for diabetes prevention.
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