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Mosquito-Associated Virus Isolation from Field-Collected Mosquitoes

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Published on: August 31, 2022

[Morbilliviruses].

Fumio Seki¹, Makoto Takeda

¹Department of Virology III, National Institute of Infectious Diseases.

|October 25, 2013

Summary

This summary is machine-generated.

Morbillivirus infections are controlled by vaccination and surveillance. The measles virus uses both SLAM and nectin4 cell receptors for infection, impacting its pathogenicity.

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Area of Science:

Virology
Immunology

Context:

Morbillivirus, part of Paramyxoviridae, includes significant human and animal pathogens.
Effective control of morbillivirus is achieved through vaccination and surveillance due to host specificity and serological monotypy.
Rinderpest virus eradication and global measles virus elimination efforts highlight successful control strategies.

Purpose:

To detail the host cell receptors utilized by measles virus.
To elucidate the roles of SLAM and nectin4 in morbillivirus infectivity and pathogenicity.

Summary:

Morbillivirus infections, significant in medicine and veterinary fields, are typically managed via vaccination and surveillance.
Recent research identified nectin4 as a novel cell receptor for measles virus.
Both SLAM (on immune cells) and nectin4 (on epithelial cells) are crucial for measles virus infectivity and pathogenicity.

Impact:

Understanding morbillivirus cell receptors like SLAM and nectin4 is vital for developing new antiviral strategies.
This knowledge aids in advancing global efforts to control and eliminate diseases caused by morbilliviruses, such as measles.
The identification of nectin4 expands our comprehension of paramyxovirus-host interactions.