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Tumor Progression02:07

Tumor Progression

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Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
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Related Experiment Video

Updated: May 6, 2026

A Mouse Model of Incompletely Resected Soft Tissue Sarcoma for Testing Neoadjuvant Therapies
07:15

A Mouse Model of Incompletely Resected Soft Tissue Sarcoma for Testing Neoadjuvant Therapies

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[Atypical tumor regression].

B Heitplatz1, K-M Müller

  • 1Gerhard-Domagk-Institut für Pathologie, Albert-Schweitzer-Campus 1, Gebäude D17, 48149, Münster, Deutschland, barbara.heitplatz@ukmuenster.de.

Der Pathologe
|October 25, 2013
PubMed
Summary

This study reports a rare case of complete esophageal squamous cell carcinoma regression following neoadjuvant therapy. The patient

Area of Science:

  • Oncology and Pathology
  • Gastroenterology
  • Immunology

Background:

  • Esophageal squamous cell carcinoma (ESCC) is a significant cause of cancer mortality.
  • Neoadjuvant radiochemotherapy is a standard treatment for locally advanced ESCC.
  • Understanding tumor response and regression patterns is crucial for treatment optimization.

Observation:

  • A 67-year-old male patient with ESCC received neoadjuvant radiochemotherapy.
  • Post-treatment analysis revealed diffuse polymorphic and anuclear cell residues.
  • Immunohistochemistry showed positive PanCK/AE1-3 staining and negative CD68/MIB1.

Findings:

  • Electron microscopy confirmed avital, akaryote cell residues indicative of tumor regression.
  • The patient's history of chronic polyarthritis and long-term use of Humira (adalimumab) and methotrexate was noted.

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  • Complete tumor regression (Level IV) was diagnosed, with no vital residual tumor tissue.

    • Implications:

    • The findings suggest a potential role of immunosuppressive therapy in modulating tumor response to neoadjuvant treatment.
    • This case highlights a unique pattern of tumor regression, potentially influenced by the patient's medical history and medications.
    • Further research is warranted to explore the interaction between immunosuppressive agents and cancer treatment outcomes.