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Updated: Jan 4, 2026

Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting
Published on: May 1, 2015
[Thoracic lymphatic system-principles, characteristics and advice for the practice]
M Schirren1, S Sponholz2, G Karaindros2
1Klinik für Thoraxchirurgie, Agaplesion Markus Krankenhaus Frankfurt, Wilhelm-Epstein-Straße 4, 60431, Frankfurt am Main, Deutschland. moritz.schirren@fdk.info.
Abstract:
The lymphatic system of the lungs is complex. To maintain an effective gas exchange there is a need for a dense lymphatic network. The alveolae have no lymphatic vessels. There is no segment-specific lymph drainage. For both lungs there are fixed bronchopulmonary lymph nodes but the number and size of the lymph nodes are variable. There are seven mediastinal lymph node chains that vary in extent, each of which acts as an independent functional unit. The accurate assessment of the nodal status needs a simple reproducible nodal map. The division into compartments or zones makes this easier. Mediastinal lymph node metastases without involvement of bronchopulmonary lymph nodes are possible. The development mechanism of this skip metastasizing is multifactorial.
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