Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Inflammation01:38

Inflammation

46.8K
Overview
46.8K
T Cell Types and Functions01:24

T Cell Types and Functions

3.2K
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
3.2K
Atherosclerosis I: Introduction01:30

Atherosclerosis I: Introduction

2.5K
Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
2.5K
Atherosclerosis II: Clinical Manifestations and Diagnostic Tests01:27

Atherosclerosis II: Clinical Manifestations and Diagnostic Tests

961
Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...
961
T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

13.7K
T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
13.7K
Atherosclerosis III: Management01:26

Atherosclerosis III: Management

747
Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
747

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

MPXV H3L elicits broadly directed CD4 T cell responses in mpox patients and MVA vaccinees.

Npj viruses·2026
Same author

Nur77 Is Associated With Polyfunctional Properties in Virus-Specific Human CD8<sup>+</sup> T Cells.

European journal of immunology·2026
Same author

Computational design of HLA class I superbinders for broad T cell immunogenicity.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Author Correction: Autoimmune response to C9orf72 protein in amyotrophic lateral sclerosis.

Nature·2026
Same author

Identification of immunodominant T cell epitopes in SARS-CoV-2 spike protein in Syrian hamsters.

Journal of immunology (Baltimore, Md. : 1950)·2026
Same author

The GF-NEO discovery platform unveils a [KQE][DG] sequence motif within fusion neoantigens in pediatric cancer.

iScience·2026

Related Experiment Video

Updated: May 6, 2026

Flow Cytometry Analysis of Immune Cells Within Murine Aortas
15:15

Flow Cytometry Analysis of Immune Cells Within Murine Aortas

Published on: July 1, 2011

34.3K

T cells in atherosclerosis.

Kevin Tse1, Harley Tse, John Sidney

  • 1Department of Internal Medicine, Division of Rheumatology, Allergy and Immunology, University of California at San Diego Medical Center, La Jolla, CA 92093, USA.

International Immunology
|October 25, 2013
PubMed
Summary
This summary is machine-generated.

This review explores T-lymphocyte subsets in atherosclerosis. While T helper 1 (T(h)1) and NKT cells promote disease, regulatory T (T(reg)) cells protect against atherosclerosis, highlighting targeted therapeutic potential.

Keywords:
T cellatherosclerosisinflammation

More Related Videos

A Human Ex Vivo Atherosclerotic Plaque Model to Study Lesion Biology
05:51

A Human Ex Vivo Atherosclerotic Plaque Model to Study Lesion Biology

Published on: May 6, 2014

13.0K
Three-Dimensional Imaging of Aortic Tissues in Atherosclerosis
09:55

Three-Dimensional Imaging of Aortic Tissues in Atherosclerosis

Published on: October 25, 2024

1.5K

Related Experiment Videos

Last Updated: May 6, 2026

Flow Cytometry Analysis of Immune Cells Within Murine Aortas
15:15

Flow Cytometry Analysis of Immune Cells Within Murine Aortas

Published on: July 1, 2011

34.3K
A Human Ex Vivo Atherosclerotic Plaque Model to Study Lesion Biology
05:51

A Human Ex Vivo Atherosclerotic Plaque Model to Study Lesion Biology

Published on: May 6, 2014

13.0K
Three-Dimensional Imaging of Aortic Tissues in Atherosclerosis
09:55

Three-Dimensional Imaging of Aortic Tissues in Atherosclerosis

Published on: October 25, 2024

1.5K

Area of Science:

  • Immunology
  • Cardiovascular Medicine
  • Inflammation Biology

Background:

  • Atherosclerosis is a chronic inflammatory artery disease.
  • Lesions involve monocytes, macrophages, smooth muscle cells, and T lymphocytes.

Purpose of the Study:

  • To review the diverse roles of T-lymphocyte subsets in atherosclerosis.
  • To identify knowledge gaps in T-cell involvement and antigen specificity.

Main Methods:

  • Literature review of T-lymphocyte subsets in atherosclerosis.
  • Analysis of CD4+ T cells (T(h)1, T(reg), T(h)2, T(h)17), CD8+ T cells, follicular helper T cells, and NKT cells.

Main Results:

  • T(h)1 and NKT cells are pro-atherogenic.
  • Regulatory T (T(reg)) cells are athero-protective.
  • Roles of T(h)2, T(h)17, CD8+ T cells, and follicular helper T cells are unclear.

Conclusions:

  • Understanding T-cell subsets is crucial for atherosclerosis pathogenesis.
  • Further research into antigen specificity is needed for targeted therapies.