Glycine receptors and brain development
Ariel Avila1, Laurent Nguyen, Jean-Michel Rigo
1Cell Physiology, BIOMED Research Institute, Hasselt University Diepenbeek, Belgium ; Groupe Interdisciplinaire Génoprotéomique Appliquée-Neurosciences, Centre Hospitalier Universitaire Sart Tilman, University of Liége Liège, Belgium ; Groupe Interdisciplinaire Génoprotéomique Appliquée-Research, Centre Hospitalier Universitaire Sart Tilman, University of Liège Liège, Belgium.
Abstract:
Glycine receptors (GlyRs) are ligand-gated chloride ion channels that mediate fast inhibitory neurotransmission in the spinal cord and the brainstem. There, they are mainly involved in motor control and pain perception in the adult. However, these receptors are also expressed in upper regions of the central nervous system, where they participate in different processes including synaptic neurotransmission. Moreover, GlyRs are present since early stages of brain development and might influence this process. Here, we discuss the current state of the art regarding GlyRs during embryonic and postnatal brain development in light of recent findings about the cellular and molecular mechanisms that control brain development.
More Related Videos
Related Concept Videos
Ligand-Gated Ion Channel Receptor: Gating Mechanism
Gut-Brain Axis
G Protein-coupled Receptors
GPCRs are also called heptahelical, 7TM, or serpentine receptors, and consist of seven (H1-H7) transmembrane alpha-helices that span the bilayer to form a cylindrical core. The transmembrane helices are connected by three extracellular loops and three...
G-protein Coupled Receptors
Transducer Mechanism: G Protein–Coupled Receptors
GPCRs are also called heptahelical,...
Neurotransmitters


