Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Ligand-Gated Ion Channel Receptor: Gating Mechanism01:30

Ligand-Gated Ion Channel Receptor: Gating Mechanism

4.6K
Ligand-gated ion channels are transmembrane proteins that play a vital role in intercellular communication and functions of the nervous system. They allow the influx of ions across the membrane once the neurotransmitter binds, allowing the subsequent transmission of electrical excitation across the neurons. Other ligand-gated ion channels, like the γ-aminobutyric acid (GABA) receptor, permit anions like chloride into the cells on the binding of the GABA molecule. Their entry into the cell...
4.6K
Gut-Brain Axis01:22

Gut-Brain Axis

252
The gut–brain axis is a bidirectional communication system that connects the gastrointestinal tract and the brain. This interaction is mediated through multiple pathways, including the vagus nerve, hormonal signals, immune responses, and chemical messengers produced by gut microbes.Microbial Contributions to Brain FunctionGut microbiota contributes significantly to brain function by producing neuroactive compounds. These include neuroactive compounds that influence neurotransmitters such...
252
G Protein-coupled Receptors01:15

G Protein-coupled Receptors

14.2K
G Protein-Coupled Receptors or GPCRs are membrane-bound receptors that transiently associate with heterotrimeric G proteins and induce an appropriate response to sensory stimuli such as light, odors, hormones, cytokines, or neurotransmitters.
GPCRs are also called heptahelical, 7TM, or serpentine receptors, and consist of seven (H1-H7) transmembrane alpha-helices that span the bilayer to form a cylindrical core. The transmembrane helices are connected by three extracellular loops and three...
14.2K
G-protein Coupled Receptors01:21

G-protein Coupled Receptors

92.8K
G-protein coupled receptors are ligand binding receptors that indirectly affect changes in the cell. The actual receptor is a single polypeptide that transverses the cell membrane seven times creating intracellular and extracellular loops. The extracellular loops create a ligand specific pocket which binds to neurotransmitters or hormones. The intracellular loops holds onto the G-protein.
92.8K
Transducer Mechanism: G Protein–Coupled Receptors01:30

Transducer Mechanism: G Protein–Coupled Receptors

9.1K
G Protein–Coupled Receptors (GPCRs) are membrane-bound receptors that transiently associate with heterotrimeric G proteins and induce an appropriate response to various stimuli. GPCRs regulate critical physiological pathways and are excellent drug targets for treating diseases such as diabetes, cancer, obesity, depression, or Alzheimer's. Nearly 35% of approved drugs implement their therapeutic effects by selectively interacting with specific GPCRs.
GPCRs are also called heptahelical,...
9.1K
Neurotransmitters01:31

Neurotransmitters

4.0K
Neurotransmitters are essential chemical messengers within the nervous system, facilitating the communication between neurons. These chemical messengers, varying in function and effect, are critical for sustaining various aspects of neurological health and emotional well-being.
4.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

RBMX functional retrocopy safeguards brain development in a species-dependent context.

Brain : a journal of neurology·2026
Same author

Cdk7 promotes neuritogenesis in cortical neurons and contributes to social behavior in mice.

Cellular and molecular life sciences : CMLS·2026
Same author

Developmental gene expression patterns driving species-specific cortical features.

Nature·2026
Same author

Protocol for whole-cell patch-clamp recording and post hoc identification of hippocampal CA2 pyramidal neurons in adult mouse brain slices.

STAR protocols·2026
Same author

Sex Differences and Survival Among COPD Patients in France: The Palomb Cohort.

International journal of chronic obstructive pulmonary disease·2026
Same author

TRPV4 Deficiency Shifts Mitochondrial Dynamics Toward a Fragmented Morphology in Primary Microglia.

Cells·2026

Related Experiment Video

Updated: May 6, 2026

Inhibitory Synapse Formation in a Co-culture Model Incorporating GABAergic Medium Spiny Neurons and HEK293 Cells Stably Expressing GABAA Receptors
07:51

Inhibitory Synapse Formation in a Co-culture Model Incorporating GABAergic Medium Spiny Neurons and HEK293 Cells Stably Expressing GABAA Receptors

Published on: November 14, 2014

19.5K

Glycine receptors and brain development.

Ariel Avila1, Laurent Nguyen, Jean-Michel Rigo

  • 1Cell Physiology, BIOMED Research Institute, Hasselt University Diepenbeek, Belgium ; Groupe Interdisciplinaire Génoprotéomique Appliquée-Neurosciences, Centre Hospitalier Universitaire Sart Tilman, University of Liége Liège, Belgium ; Groupe Interdisciplinaire Génoprotéomique Appliquée-Research, Centre Hospitalier Universitaire Sart Tilman, University of Liège Liège, Belgium.

Frontiers in Cellular Neuroscience
|October 25, 2013
PubMed
Summary

Glycine receptors (GlyRs) are crucial for brain development, influencing neurotransmission from early embryonic stages through postnatal life. Understanding their role is key to comprehending neural circuit formation and function.

Keywords:
GlyRsbrain developmentcortexglycineglycine receptorshippocampusinterneuronsmigration

More Related Videos

A High-throughput Calcium-flux Assay to Study NMDA-receptors with Sensitivity to Glycine/D-serine and Glutamate
04:48

A High-throughput Calcium-flux Assay to Study NMDA-receptors with Sensitivity to Glycine/D-serine and Glutamate

Published on: July 10, 2018

8.7K
Using an α-Bungarotoxin Binding Site Tag to Study GABA A Receptor Membrane Localization and Trafficking
11:57

Using an α-Bungarotoxin Binding Site Tag to Study GABA A Receptor Membrane Localization and Trafficking

Published on: March 28, 2014

14.8K

Related Experiment Videos

Last Updated: May 6, 2026

Inhibitory Synapse Formation in a Co-culture Model Incorporating GABAergic Medium Spiny Neurons and HEK293 Cells Stably Expressing GABAA Receptors
07:51

Inhibitory Synapse Formation in a Co-culture Model Incorporating GABAergic Medium Spiny Neurons and HEK293 Cells Stably Expressing GABAA Receptors

Published on: November 14, 2014

19.5K
A High-throughput Calcium-flux Assay to Study NMDA-receptors with Sensitivity to Glycine/D-serine and Glutamate
04:48

A High-throughput Calcium-flux Assay to Study NMDA-receptors with Sensitivity to Glycine/D-serine and Glutamate

Published on: July 10, 2018

8.7K
Using an α-Bungarotoxin Binding Site Tag to Study GABA A Receptor Membrane Localization and Trafficking
11:57

Using an α-Bungarotoxin Binding Site Tag to Study GABA A Receptor Membrane Localization and Trafficking

Published on: March 28, 2014

14.8K

Area of Science:

  • Neuroscience
  • Developmental Biology
  • Molecular Biology

Background:

  • Glycine receptors (GlyRs) are ligand-gated chloride channels mediating inhibitory neurotransmission.
  • In adults, GlyRs are primarily involved in motor control and pain perception in the spinal cord and brainstem.
  • GlyRs are also found in higher brain regions and are present during early brain development.

Purpose of the Study:

  • To review the current understanding of Glycine receptors' function during embryonic and postnatal brain development.
  • To highlight recent findings on cellular and molecular mechanisms governing brain development in relation to GlyRs.

Main Methods:

  • Literature review and synthesis of recent research findings.
  • Discussion of cellular and molecular mechanisms impacting brain development.
  • Focus on the role of Glycine receptors throughout development.

Main Results:

  • Glycine receptors play a significant role in early brain development.
  • GlyRs influence various developmental processes beyond their known adult functions.
  • Recent studies provide new insights into the molecular and cellular regulation of GlyRs during development.

Conclusions:

  • Glycine receptors are critical regulators of embryonic and postnatal brain development.
  • Further research into GlyR function during development can illuminate mechanisms of neural circuit formation.
  • Understanding GlyRs offers potential insights into developmental neurological disorders.