Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Pervasive Negative Regulation of Ion Channel Functional Families Across Human Cancers.

American journal of physiology. Cell physiology·2026
Same author

Targeting the US21 viroporin of human cytomegalovirus by calcium channel blockers as a new antiviral strategy.

Current research in microbial sciences·2026
Same author

Spatio-spectral light-by-light moulding in multimode fibre.

Nature communications·2026
Same author

The ion transport, GPCR, and RTK toolkit expression in the human cerebrovascular endothelial cell line, hCMEC/D3: an Omics perspective.

Frontiers in physiology·2026
Same author

Intracellular calcium-induced ROS generation promotes squaraine phototoxicity.

Biochimica et biophysica acta. Molecular cell research·2025
Same author

Intermodal all-optical pulse switching and frequency conversion using temporal reflection and refraction in multimode fibers.

Nanophotonics (Berlin, Germany)·2025

Related Experiment Video

Updated: May 6, 2026

Functional Calcium Imaging in Developing Cortical Networks
16:33

Functional Calcium Imaging in Developing Cortical Networks

Published on: October 22, 2011

41.4K

Spatial wavelet analysis of calcium oscillations in developing neurons.

Federico Alessandro Ruffinatti1, Alessandra Gilardino, Davide Lovisolo

  • 1Department of Life Sciences and Systems Biology, University of Turin, Turin, Italy ; NIS Interdepartmental Center, University of Turin, Turin, Italy.

Plos One
|October 25, 2013
PubMed
Summary

Calcium signals guide neuronal development. This study separates geometry from function, revealing distinct calcium oscillation patterns in different neuronal regions, crucial for understanding neuronal information coding.

More Related Videos

Fluorescent Calcium Imaging and Subsequent In Situ Hybridization for Neuronal Precursor Characterization in Xenopus laevis
09:07

Fluorescent Calcium Imaging and Subsequent In Situ Hybridization for Neuronal Precursor Characterization in Xenopus laevis

Published on: February 18, 2020

9.4K
Applications of Spatio-temporal Mapping and Particle Analysis Techniques to Quantify Intracellular Ca2+ Signaling In Situ
09:34

Applications of Spatio-temporal Mapping and Particle Analysis Techniques to Quantify Intracellular Ca2+ Signaling In Situ

Published on: January 7, 2019

8.0K

Related Experiment Videos

Last Updated: May 6, 2026

Functional Calcium Imaging in Developing Cortical Networks
16:33

Functional Calcium Imaging in Developing Cortical Networks

Published on: October 22, 2011

41.4K
Fluorescent Calcium Imaging and Subsequent In Situ Hybridization for Neuronal Precursor Characterization in Xenopus laevis
09:07

Fluorescent Calcium Imaging and Subsequent In Situ Hybridization for Neuronal Precursor Characterization in Xenopus laevis

Published on: February 18, 2020

9.4K
Applications of Spatio-temporal Mapping and Particle Analysis Techniques to Quantify Intracellular Ca2+ Signaling In Situ
09:34

Applications of Spatio-temporal Mapping and Particle Analysis Techniques to Quantify Intracellular Ca2+ Signaling In Situ

Published on: January 7, 2019

8.0K

Area of Science:

  • Neuroscience
  • Cell Biology
  • Developmental Biology

Background:

  • Calcium signals are critical for neuronal development, influencing neuritic growth and orientation.
  • Neuronal information processing relies on spatially compartmentalized calcium signals.
  • Understanding the basis of this compartmentalization (geometry vs. specific mechanisms) is essential.

Purpose of the Study:

  • To develop a novel method to distinguish geometrical from functional contributions to calcium signal compartmentalization.
  • To investigate the spatial patterns of cytosolic calcium concentration oscillations in developing neurons.
  • To determine whether observed calcium dynamics variations are due to cell geometry or specific ion transport mechanisms.

Main Methods:

  • A wavelet-theoretic approach was used to derive spatial indices measuring calcium concentration oscillations in specific regions of interest (ROIs).
  • Correlation functions were computed between activity indices and the surface-to-volume ratio along the neuron.
  • Statistical analysis was performed on a dataset of 100 cells to validate findings.

Main Results:

  • Distinct patterns of calcium oscillations were observed in different ROIs along developing chick ciliary ganglion neurons.
  • Calcium dynamics in the soma showed a strong correlation with the surface-to-volume ratio.
  • In the growth cone-neurite region, correlations between calcium dynamics and surface-to-volume ratio decreased significantly.

Conclusions:

  • Neuronal calcium signaling exhibits significant spatial compartmentalization.
  • Soma calcium dynamics are largely influenced by geometrical factors (surface-to-volume ratio).
  • The growth cone-neurite region's calcium dynamics are primarily governed by specific calcium influx/efflux mechanisms, not just geometry.