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[Fertility on women with Turner syndrome]
Zeina Chakhtoura1, Philippe Touraine
1Groupe hospitalier La Pitié-Salpêtrière - Charles-Foix, endocrinologie et médecine de la reproduction, université Paris-6-Pierre-et-Marie-Curie, 75013 Paris, France; Centre de référence des maladies endocriniennes rares de la croissance, AP-HP, 75019 Paris, France; Centre des pathologies gynécologiques médico-chirurgicales rares, 75015 Paris, France.
Abstract:
Spontaneous pregnancies occur in 1.8 to 7.6% among women with Turner syndrome. A genetic counseling is required before conception because only 30 to 40% of these pregnancies lead to the birth of a healthy child. A check-up has to be done before pregnancy, and if authorized, it will be tightly followed-up. Pregnancy is contraindicated if cardiac or aortic malformations exist, except for bicuspid aortic valve. Teams advice single embryo transfer. Rates of pregnancies of 45 to 60% after oocyte donation, but 40 to 60% of spontaneous abortions are noted, due to uterine factors. A study is trying to define patients who could postulate to cryopreservation of ovarian tissue.
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