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Functional t1ρ imaging in panic disorder.

Vincent A Magnotta1, Casey P Johnson2, Robin Follmer3

  • 1Department of Radiology, University of Iowa, Iowa City, Iowa; Department of Biomedical Engineering, University of Iowa, Iowa City, Iowa; Department of Psychiatry, University of Iowa, Iowa City, Iowa.

Biological Psychiatry
|October 26, 2013
PubMed
Summary
This summary is machine-generated.

Panic disorder may involve abnormal brain pH, as indicated by greater T1ρ (T1 relaxation in the rotating frame) signal changes in visual and anterior cingulate cortices. This pH-sensitive imaging offers insights distinct from BOLD imaging.

Keywords:
BOLDT1ρbrain activationbrain pHmetabolismpanic disorder

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Area of Science:

  • Neuroimaging
  • Psychiatry
  • Biophysics

Background:

  • Abnormal brain pH is implicated in panic disorder.
  • Investigated pH-sensitive magnetic resonance (MR) imaging (T1 relaxation in the rotating frame [T1ρ]) and conventional blood oxygen level-dependent (BOLD) imaging.

Purpose of the Study:

  • To investigate the role of brain pH in panic disorder using advanced MR imaging techniques.
  • To compare the efficacy of T1ρ imaging versus BOLD imaging in detecting functional brain differences in panic disorder.

Main Methods:

  • Enrolled 13 panic disorder participants and 13 matched controls.
  • Utilized T1ρ and BOLD imaging during visual stimulation (flashing checkerboard).
  • Assessed panic symptoms using the Beck Anxiety Inventory.

Main Results:

  • T1ρ imaging showed greater visual cortex activation in panic disorder patients.
  • T1ρ detected stimulus-evoked decreases in the anterior cingulate cortex.
  • BOLD imaging revealed no significant group differences.
  • T1ρ signal correlated with panic symptoms in specific brain regions (inferior parietal lobe, middle temporal gyrus, insula).

Conclusions:

  • Panic disorder patients exhibit greater activity-evoked T1ρ changes in the visual and anterior cingulate cortices.
  • Findings support the hypothesis of pH dysregulation in panic disorder.
  • T1ρ imaging provides unique insights into panic disorder, potentially reflecting pH and brain metabolism abnormalities, distinct from BOLD imaging.