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Related Concept Videos

Drugs for Treatment of Crohn's Disease in IBD Using Glucocorticoids01:21

Drugs for Treatment of Crohn's Disease in IBD Using Glucocorticoids

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Glucocorticoids, a class of anti-inflammatory drugs, are pivotal in treating moderate to severe Crohn's disease by inducing remission. They exhibit their anti-inflammatory action by inhibiting the production of inflammatory cytokines such as tumor necrosis factor (TNF)-α, interleukin (IL)-1, and chemokines like IL-8. In addition, they reduce the expression of inflammatory cell adhesion molecules and inhibit gene transcription of nitric oxide synthase, phospholipase A2, cyclooxygenase-2...
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Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF01:24

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Tumor Necrosis Factor (TNF), a proinflammatory cytokine, contributes significantly to the inflammation seen in Crohn's disease. It exists as soluble TNF and membrane-bound TNF, with actions mediated through TNF receptors (TNFR). TNFR activation leads to the release of proinflammatory cytokines, T-cell activation, collagen production, and leukocyte migration, all contributing to inflammation in Crohn's disease. Anti-TNF monoclonal antibodies, namely infliximab (Remicade), adalimumab...
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Inflammatory Bowel Disease IV: Pharmacological Management01:29

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Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...
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Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents01:29

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Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel...
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Drugs for Treatment of Ulcerative Colitis in IBD01:29

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Ulcerative colitis is a chronic inflammatory condition primarily affecting the colon and rectum. The primary drugs used in the treatment of ulcerative colitis are aminosalicylates. They exhibit anti-inflammatory and immunosuppressive properties. They modulate inflammatory mediators and inhibit the activity of nuclear factor κB (NF-κB). Aminosalicylates also reduce inflammation by inhibiting prostaglandin and leukotriene production and decreasing neutrophil chemotaxis and superoxide...
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Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

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Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
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Related Experiment Video

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Cell therapies for IBD: what works?

Elena Ricart1, Aranzazu Jauregui-Amezaga, Ingrid Ordás

  • 1Gastroenterology Department, Hospital Clinic, C/Villarroel, 170, Barcelona 08036, Spain. ericart@clinic.ub.es.

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Summary

Cellular therapies show promise for treating inflammatory bowel diseases (IBD) like Crohn's disease and ulcerative colitis when traditional drugs fall short. Approaches include stem cell therapies and specialized immune cell treatments.

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Area of Science:

  • Immunology
  • Gastroenterology
  • Regenerative Medicine

Background:

  • Inflammatory bowel disease (IBD) involves complex, self-amplifying inflammatory responses.
  • Current treatments like anti-TNF antibodies and corticosteroids offer insufficient relief for many Crohn's disease and ulcerative colitis patients.

Purpose of the Study:

  • To explore emerging cellular therapies as novel treatment strategies for IBD.
  • To review the current landscape of cell-based interventions for immune-mediated gastrointestinal diseases.

Main Methods:

  • Review of experimental and clinical data on cell therapies for immune-mediated diseases.
  • Categorization of cell therapies into hematopoietic stem cell therapies and selected/conditioned immune cell therapies.

Main Results:

  • Cellular therapies are increasingly utilized for severe immune-mediated diseases, including IBD.
  • Key cell therapy types include mesenchymal stem cells and T-regulatory cells.

Conclusions:

  • Cellular therapies represent a promising frontier for managing inflammatory bowel diseases.
  • These novel approaches may offer new hope for patients with refractory Crohn's disease and ulcerative colitis.