Related Experiment Video

Updated: May 6, 2026

Author Spotlight: Advancing Pediatric Epilepsy Surgery in Children Through Novel Biomarkers and Enhanced Localization
09:57

Author Spotlight: Advancing Pediatric Epilepsy Surgery in Children Through Novel Biomarkers and Enhanced Localization

Published on: September 20, 2024

3.5K

Electrographic seizures after convulsive status epilepticus in children and young adults: a retrospective multicenter

Iván Sánchez Fernández1, Nicholas S Abend2, Daniel H Arndt3

  • 1Division of Epilepsy and Clinical Neurophysiology, Department of Neurology, Boston Children's Hospital, Harvard Medical School, Boston, MA; Department of Child Neurology, Hospital Sant Joan de Déu, Universidad de Barcelona, Barcelona, Spain.

The Journal of Pediatrics
|October 29, 2013
PubMed

Insights

One-third of children with convulsive status epilepticus (CSE) experienced electrographic seizures, with some having seizures not visible clinically. Prior epilepsy diagnosis and epileptiform discharges predict these seizures.

Area of Science:

  • Pediatric Neurology
  • Epileptology
  • Clinical Neurophysiology

Background:

  • Convulsive status epilepticus (CSE) is a medical emergency in children.
  • The occurrence and predictors of electrographic seizures following CSE are not well-defined.

Purpose of the Study:

  • To determine the prevalence and characteristics of electrographic seizures after CSE in children.
  • To identify predictors and clinical outcomes associated with post-CSE electrographic seizures.

Main Methods:

  • Multicenter retrospective study involving children aged 1 month to 21 years.
  • Continuous electroencephalographic (EEG) monitoring was performed after CSE.
  • Clinical and EEG data were analyzed to identify electrographic seizures and associated factors.

Main Results:

  • Electrographic seizures occurred in 33% of 98 children following CSE.
  • Electrographic-only seizures were present in 34.4% of those with electrographic seizures.
  • Predictors included a prior epilepsy diagnosis (P=.029) and interictal epileptiform discharges (P<.0005).
  • Children with electrographic seizures had longer PICU stays (9.5 vs 2 days, P=.0001).

Conclusions:

  • Approximately one-third of children with CSE develop electrographic seizures, some without clinical manifestations.
  • A history of epilepsy and interictal epileptiform discharges are significant risk factors.
  • The findings highlight the importance of continuous EEG monitoring in children post-CSE.
Abstract

Keywords:
CSEConvulsive status epilepticusEEGElectroencephalogram

More Related Videos

Interictal High Frequency Oscillations Detected with Simultaneous Magnetoencephalography and Electroencephalography as Biomarker of Pediatric Epilepsy10:22

Interictal High Frequency Oscillations Detected with Simultaneous Magnetoencephalography and Electroencephalography as Biomarker of Pediatric Epilepsy

Published on: December 6, 2016

22.8K
Performing Behavioral Tasks in Subjects with Intracranial Electrodes12:10

Performing Behavioral Tasks in Subjects with Intracranial Electrodes

Published on: October 2, 2014

11.1K

Related Concept Videos

Seizures l: Introduction01:20

Seizures l: Introduction

Understanding seizures and epilepsy relies on key definitions that help in recognizing, classifying, and managing these disorders. These definitions provide a framework for recognizing, classifying, and managing seizure disorders.DefinitionsA seizure is a sudden, abnormal burst of electrical activity in the brain that can cause changes in awareness, movement, sensation, or behavior, depending on the area involved. Epilepsy is a chronic condition characterized by recurrent, unprovoked seizures,...
43
Seizures: Classification01:13

Seizures: Classification

Epilepsy is primarily characterized by unpredictable seizures, either provoked by an identifiable factor, such as injury or illness, or unprovoked, occurring spontaneously without apparent cause.
Seizures are typically classified into two main categories: focal and generalized seizures.
Focal Seizures
Focal seizures originate from specific regions of the brain. These seizures are further sub-classified into two types:
2.5K
Epilepsy and Seizures: Overview01:24

Epilepsy and Seizures: Overview

Epilepsy is a chronic neurological disease marked by recurrent, unpredictable seizures. These seizures are caused by abnormal electrical discharges in the brain, leading to behavior, sensation, or consciousness alterations. They can also cause transient impairment of awareness, interfering with daily activities.
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...
1.8K
Epilepsy ll: Types01:22

Epilepsy ll: Types

Recurrent seizures, stemming from abnormal electrical activity in the brain, are the defining characteristic of epilepsy, a chronic neurological condition. Because seizure features vary greatly, epilepsy is classified using two systems: by seizure type and by epilepsy syndromes. These classifications enable clinicians to describe seizure patterns and select suitable treatment strategies.I. Classification by Seizure Type1. Focal EpilepsyFocal epilepsy begins in one hemisphere of the brain.
73
Electroconvulsive Therapy01:30

Electroconvulsive Therapy

Electroconvulsive therapy (ECT), or shock therapy, remains a critical biomedical intervention for severe, treatment-resistant depression. While its origins can be traced back to Hippocrates' observations that malaria-induced convulsions alleviated mental illness, modern ECT has evolved significantly from its earlier, more primitive applications. First introduced in 1938 by Ugo Cerletti and his colleagues, ECT involves inducing controlled seizures using electrical currents. In its early...
2.6K
Seizures ll: Types01:19

Seizures ll: Types

Seizures are sudden bursts of abnormal electrical discharge in the brain that interfere with normal function. They are commonly divided into three groups: focal seizures, generalized seizures, and other types that do not fit neatly into either category.Focal SeizuresFocal seizures begin in a single brain region. When awareness is preserved, they are called focal aware seizures and may cause sensations such as tingling, unusual smells, or flashing lights. When awareness is impaired, they are...
44