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Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice
Published on: June 8, 2022
[Lupus nephropathy in black patients with systemic lupus erythematosus in Senegal: 43 cases]
E F Ka1, M M Cisse, A T Lemrabott
1Service de néphrologie.
Insights
This study found that 72% of patients with systemic lupus erythematosus (SLE) had lupus nephritis, a kidney complication. Lupus nephritis significantly impacts renal function and outcomes in affected individuals.
Area of Science:
- Nephrology
- Rheumatology
- Internal Medicine
Background:
- Systemic lupus erythematosus (SLE) is a chronic autoimmune disease.
- Lupus nephropathy (LN) is a common and serious complication of SLE.
- Understanding LN prevalence and profiles is crucial for patient management.
Purpose of the Study:
- To determine the prevalence of lupus nephropathy in a specific patient cohort.
- To analyze the clinical, histological, therapeutic, and outcome characteristics of lupus nephropathy.
- To identify demographic and disease-related factors influencing LN.
Main Methods:
- Retrospective study design.
- Analysis of patient records from 1999-2009 at Aristide Le Dantec University Hospital Center.
- Inclusion of 43 patients with SLE, focusing on those with lupus nephritis.
Main Results:
- 72% of SLE patients exhibited lupus nephritis.
- Mean age of patients was 32.9 years, with a female predominance (40 women, 3 men).
- Lupus nephritis was the initial presentation of SLE in 27.9% of cases. Mean proteinuria was 2.01 g/dL. Renal biopsies revealed varying nephritis classes (II, IV, V).
- Combined corticosteroid and immunosuppressant therapy was used in 15 patients. Mortality occurred in 4 patients due to SLE activity, renal failure complications, or sepsis.
Conclusions:
- Lupus nephritis is highly prevalent in SLE patients within the studied population.
- Diverse histological classes and significant renal impairment were observed.
- Further research with larger cohorts, particularly in sub-Saharan Africa, is needed to accurately assess LN prevalence and severity.
Unlabelled:
This study sought to assess the prevalence of lupus nephropathy and to determine its clinical, histological, therapeutic and outcome profiles.
Patients And Methods:
This retrospective study examined records covering a 10-year period from 1999 to 2009 at the nephrology department of the Aristide Le Dantec University Hospital Center.
Results:
The records showed 43 patients with systemic lupus erythematosus (SLE), and 72% had lupus nephritis. The patients' mean age was 32.9 years; 40 were women and 3 men, for a sex ratio of 0.075. The lupus nephritis led to discovery of SLE in 27.9%. The mean proteinuria concentration was 2.01 g/dL. Seventeen patients had impaired renal function, and 26 had renal biopsies. It found class II nephritis in 2 patients, class IV in 10, and class V in 12. In addition, fifteen patients received combined corticosteroid + immunosuppressant treatment. Four patients died during the study period, one from SLE activity, two from complications of renal failure, and the fourth from sepsis.
Conclusion:
A larger study would be useful to assess more acurately the prevalence of various classes and severity of lupus nephropathy among blacks living in sub-Saharan Africa.
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