Lupus erythematosus-like eruption from captopril.

Area of Science:

• Dermatology
• Pharmacology
• Pathology

Background:

• Angiotensin-converting enzyme (ACE) inhibitors, such as Captopril, are widely prescribed for hypertension and heart failure.
• Cutaneous adverse drug reactions (ADRs) are common, ranging from mild rashes to severe, life-threatening conditions.
• Subacute cutaneous lupus erythematosus (SCLE) is an autoimmune condition characterized by photosensitive skin lesions.

Observation:

• A case report details a patient undergoing Captopril therapy.
• The patient presented with a dermatitis exhibiting clinical characteristics similar to gyrate subacute lupus erythematosus.
• Light microscopy revealed lichenoid features within the skin biopsy.

Findings:

• The observed dermatitis in the patient on Captopril treatment mimicked gyrate subacute lupus erythematosus.
• Histopathological examination confirmed lichenoid changes, a pattern sometimes seen in drug-induced dermatoses.
• This suggests a potential link between Captopril and the development of this specific type of dermatitis.

Implications:

• This case underscores the importance of considering drug-induced dermatoses in patients presenting with lupus-like skin conditions.
• Dermatologists and clinicians should be aware of potential Captopril-associated cutaneous reactions.
• Further investigation may be warranted to elucidate the mechanisms underlying Captopril-induced dermatitis with lichenoid and SCLE-like features.