Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Computer-Assisted Hapten Design for High-Performance Recombinant Antibody against Napropamide: Molecular Recognition Insight and Dual T-Line Lateral Flow Immunoassay Development.

Analytical chemistry·2026
Same author

Spin-controlled enantioselective near-infrared photocatalysis with chiral MgO/Co<sub>3</sub>O<sub>4</sub> nanoparticles.

Nature communications·2026
Same author

Guiding point-of-care therapeutic drug monitoring through structure-toxicity principles.

Chemical science·2026
Same author

Computer-Aided Rational Hapten Design for Broad-Spectrum Monoclonal Antibody Development against Anthraquinones and Its Application in Lateral Flow Immunoassay.

Analytical chemistry·2026
Same author

Fluorescence Polarization Immunoassay with Modulated Selectivity for Effective Detection of the Agrochemical 4-Chlorophenoxyacetic Acid.

Biosensors·2026
Same author

An ultrasensitive visual detection platform for forchlorfenuron: from simulation-assisted hapten and antibody production to double-T immunochromatographic assay application.

Journal of materials chemistry. B·2026

Related Experiment Video

Updated: May 6, 2026

Assembly of Gold Nanorods into Chiral Plasmonic Metamolecules Using DNA Origami Templates
09:17

Assembly of Gold Nanorods into Chiral Plasmonic Metamolecules Using DNA Origami Templates

Published on: March 5, 2019

10.5K

Attomolar DNA detection with chiral nanorod assemblies.

Wei Ma1, Hua Kuang, Liguang Xu

  • 11] State Key Lab of Food Science and Technology, School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, China [2].

Nature Communications
|October 29, 2013
PubMed
Summary

Gold nanorods assembled using DNA form chiral structures with strong optical activity. This novel chiroplasmonic sensing method achieves attomolar DNA detection limits for bioanalysis.

More Related Videos

Engineering Molecular Recognition with Bio-mimetic Polymers on Single Walled Carbon Nanotubes
09:28

Engineering Molecular Recognition with Bio-mimetic Polymers on Single Walled Carbon Nanotubes

Published on: January 10, 2017

7.8K
Author Spotlight: Single-Molecule Surface-Enhanced Raman Scattering Measurements Enabled by Plasmonic DNA Origami Nanoantennas
10:43

Author Spotlight: Single-Molecule Surface-Enhanced Raman Scattering Measurements Enabled by Plasmonic DNA Origami Nanoantennas

Published on: July 21, 2023

3.5K

Related Experiment Videos

Last Updated: May 6, 2026

Assembly of Gold Nanorods into Chiral Plasmonic Metamolecules Using DNA Origami Templates
09:17

Assembly of Gold Nanorods into Chiral Plasmonic Metamolecules Using DNA Origami Templates

Published on: March 5, 2019

10.5K
Engineering Molecular Recognition with Bio-mimetic Polymers on Single Walled Carbon Nanotubes
09:28

Engineering Molecular Recognition with Bio-mimetic Polymers on Single Walled Carbon Nanotubes

Published on: January 10, 2017

7.8K
Author Spotlight: Single-Molecule Surface-Enhanced Raman Scattering Measurements Enabled by Plasmonic DNA Origami Nanoantennas
10:43

Author Spotlight: Single-Molecule Surface-Enhanced Raman Scattering Measurements Enabled by Plasmonic DNA Origami Nanoantennas

Published on: July 21, 2023

3.5K

Area of Science:

  • Nanotechnology
  • Plasmonics
  • Chiroptical Spectroscopy

Background:

  • Nanoscale plasmonic assemblies exhibit significant chiral optical activity.
  • Metamaterial-driven design has limited practical applications for these assemblies.
  • DNA-templated assembly offers a route to functional nanoscale chiral systems.

Purpose of the Study:

  • To demonstrate the analytical potential of DNA-assembled gold nanorod chiral systems.
  • To investigate the relationship between nanorod assembly structure and chiroplasmonic activity.
  • To establish a highly sensitive DNA detection method using chiroplasmonic sensing.

Main Methods:

  • Polymerase chain reaction (PCR) for DNA-templated assembly of gold nanorods.
  • Circular dichroism (CD) spectroscopy to measure chiroplasmonic activity.
  • Analysis of the correlation between DNA concentration and CD spectral amplitude.

Main Results:

  • DNA-bridged gold nanorod assemblies exhibit strong chiroplasmonic activity due to a specific twist angle between nanorods.
  • The circular dichroism signal shows linear dependence on the amount of target DNA.
  • An ultra-low limit of detection (LOD) of 3.7 aM for DNA was achieved.
  • The method is effective for detecting biological analytes larger than 2-5 nm.

Conclusions:

  • DNA-assembled gold nanorod systems offer promising analytical applications in bioanalysis.
  • The chiroplasmonic sensing approach provides high sensitivity and specificity for oligonucleotide detection.
  • This method has potential applications in disease diagnostics, forensics, and environmental monitoring.