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From Molecules to Materials: Engineering New Ionic Liquid Crystals Through Halogen Bonding
Published on: March 24, 2018
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Coordinating chiral ionic liquids
Maria Vasiloiu1, Sonja Leder, Peter Gaertner
1Institute of Applied Synthetic Chemistry, Vienna University of Technology, 1060 Vienna, Austria. katharina.bica@tuwien.ac.at.
Organic & Biomolecular Chemistry
|October 29, 2013
Summary
Researchers developed new chiral ionic liquids from amino alcohols. These compounds effectively catalyze asymmetric alkylation reactions, achieving high enantioselectivity up to 91% ee.
Area of Science:
- Organic Chemistry
- Catalysis
- Green Chemistry
Background:
- Chiral ionic liquids (CILs) are versatile compounds with unique properties.
- Developing efficient and accessible CILs is crucial for asymmetric synthesis.
- Amino alcohol motifs offer potential for designing novel CIL structures.
Purpose of the Study:
- To develop a practical synthesis of novel coordinating chiral ionic liquids.
- To investigate the catalytic application of these CILs in asymmetric reactions.
- To evaluate the enantioselectivity achieved in the target transformations.
Main Methods:
- Synthesis of CILs starting from commercially available amino alcohols.
- Utilizing the synthesized basic CILs as catalysts.
- Performing asymmetric alkylation of aldehydes.
Main Results:
- A practical synthetic route for novel coordinating chiral ionic liquids was established.
- The developed CILs demonstrated high catalytic activity in asymmetric alkylation.
- Enantioselectivities of up to 91% enantiomeric excess (ee) were achieved.
Conclusions:
- Novel coordinating chiral ionic liquids with amino alcohol motifs can be practically synthesized.
- These CILs are effective catalysts for asymmetric alkylation of aldehydes.
- The methodology offers a promising approach for accessing enantiomerically enriched products.
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