Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Mouse Models of Cancer Study

Mouse Models of Cancer Study

Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

CPT1a Expression Is a Critical Cardioprotective Response to Pathological Stress That Enables Rescue by Gene Transfer.

Circulation research·2025

Same author

Amelioration of Morphological Pathology in Cardiac, Respiratory, and Skeletal Muscles Following Intraosseous Administration of Human Dystrophin Expressing Chimeric (DEC) Cells in Duchenne Muscular Dystrophy Model.

Biomedicines·2024

Same author

Assessment of Motor Unit Potentials Duration as the Biomarker of DT-DEC01 Cell Therapy Efficacy in Duchenne Muscular Dystrophy Patients up to 12 Months After Systemic-Intraosseous Administration.

Archivum immunologiae et therapiae experimentalis·2023

Same author

Safety and Efficacy of DT-DEC01 Therapy in Duchenne Muscular Dystrophy Patients: A 12 - Month Follow-Up Study After Systemic Intraosseous Administration.

Stem cell reviews and reports·2023

Same author

Dystrophin Expressing Chimeric (DEC) Cell Therapy for Duchenne Muscular Dystrophy: A First-in-Human Study with Minimum 6 Months Follow-up.

Stem cell reviews and reports·2023

Same author

A Brief Review of Duchenne Muscular Dystrophy Treatment Options, with an Emphasis on Two Novel Strategies.

Biomedicines·2023

Search research articles

Related Experiment Video

Updated: May 6, 2026

Using the BLT Humanized Mouse as a Stem Cell based Gene Therapy Tumor Model

Using the BLT Humanized Mouse as a Stem Cell based Gene Therapy Tumor Model

Published on: December 18, 2012

The super super-healing MRL mouse strain.

Ahlke Heydemann¹

¹Department of Physiology and Biophysics, Center for Cardiovascular Research, The University of Illinois at Chicago, Chicago, IL 60612, USA.

Frontiers in Biology

|October 29, 2013

Summary

Murphy Roths Large (MRL/MpJ) mice exhibit scarless wound healing, regenerating tissue without fibrosis. Researchers are investigating their unique cellular and immune differences to understand this remarkable regenerative capacity.

Keywords:

MRL regeneration wound healing

More Related Videos

Refined CLARITY-Based Tissue Clearing for Three-Dimensional Fibroblast Organization in Healthy and Injured Mouse Hearts

Refined CLARITY-Based Tissue Clearing for Three-Dimensional Fibroblast Organization in Healthy and Injured Mouse Hearts

Published on: May 16, 2021

Chronic, Acute, and Reactivated HIV Infection in Humanized Immunodeficient Mouse Models

Chronic, Acute, and Reactivated HIV Infection in Humanized Immunodeficient Mouse Models

Published on: December 3, 2019

Related Experiment Videos

Last Updated: May 6, 2026

Using the BLT Humanized Mouse as a Stem Cell based Gene Therapy Tumor Model

Using the BLT Humanized Mouse as a Stem Cell based Gene Therapy Tumor Model

Published on: December 18, 2012

Refined CLARITY-Based Tissue Clearing for Three-Dimensional Fibroblast Organization in Healthy and Injured Mouse Hearts

Refined CLARITY-Based Tissue Clearing for Three-Dimensional Fibroblast Organization in Healthy and Injured Mouse Hearts

Published on: May 16, 2021

Chronic, Acute, and Reactivated HIV Infection in Humanized Immunodeficient Mouse Models

Chronic, Acute, and Reactivated HIV Infection in Humanized Immunodeficient Mouse Models

Published on: December 3, 2019

Area of Science:

Regenerative Medicine
Mammalian Wound Healing
Comparative Biology

Background:

Murphy Roths Large (MRL/MpJ) mice and related strains demonstrate scarless wound healing across various tissues.
This unique regenerative phenotype contrasts with typical fibrotic scarring observed in other mammalian models.
The underlying mechanisms driving this scarless healing remain incompletely understood.

Purpose of the Study:

To explore the biological basis of scarless wound repair in MRL/MpJ mice.
To identify key cellular and molecular differences contributing to enhanced regeneration.
To investigate potential links between regeneration and autoimmune characteristics in these mouse strains.

Main Methods:

Comparative analysis of wound healing in MRL/MpJ mice versus other strains.
Investigation of cellular processes, including reepithelialization and blastema formation.
Assessment of immune system alterations and progenitor cell characteristics.

Main Results:

MRL/MpJ cells show accelerated reepithelialization, facilitating blastema development.
These mice possess an altered basal immune system and immune response to injury.
Differences in tissue-resident progenitor cells and cell cycle regulators are observed.

Conclusions:

MRL/MpJ mice offer a valuable model for studying scarless regeneration.
Further research is needed to differentiate causative factors from corollary observations.
The relationship between regenerative ability and autoimmunity in MRL mice warrants continued investigation.