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Trabecular Meshwork Response to Pressure Elevation in the Living Human Eye
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Age-related changes in trabecular meshwork imaging.

Mark E Gold1, Seema Kansara, Kundandeep S Nagi

  • 1Ruiz Department of Ophthalmology and Visual Science, The University of Texas Medical School at Houston, 6431 Fannin Street, MSB 7.024, Houston, TX 77030, USA.

Biomed Research International
|October 29, 2013
PubMed
Summary
This summary is machine-generated.

Trabecular meshwork (TM) measurements did not change with age, but the TM interface shadow area increased in older adults. Further research is needed to understand the functional implications of these age-related changes.

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Area of Science:

  • Ophthalmology
  • Anatomy
  • Biomedical Engineering

Background:

  • The trabecular meshwork (TM) is crucial for regulating intraocular pressure.
  • Understanding age-related changes in the TM is important for diagnosing and managing glaucoma.
  • Anterior segment optical coherence tomography (ASOCT) is a valuable tool for visualizing ocular structures.

Purpose of the Study:

  • To assess the impact of normal aging on TM parameters using Fourier domain ASOCT.
  • To quantify age-related alterations in TM area, TM length, and TM interface shadow characteristics.

Main Methods:

  • ASOCT imaging was performed on one eye of 45 participants across three age groups (18-80 years).
  • Two independent readers measured TM area, TM length, and TM interface shadow area and length.
  • Stepwise regression analysis was used to compare measurements and identify age-related correlations.

Main Results:

  • Average TM area was 0.0487 mm², TM length was 0.5502 mm, TM interface shadow area was 0.1623 mm², and TM interface shadow length was 0.7755 mm.
  • TM area and length showed no correlation with age.
  • TM interface shadow area significantly increased with age, while TM interface shadow length did not.

Conclusions:

  • While direct TM measurements are age-independent, the TM interface shadow area increases with aging.
  • These findings suggest potential age-related structural changes within the TM.
  • Further investigation is warranted to link these ASOCT observations to TM function and intraocular pressure regulation.