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Updated: May 6, 2026

Ex Vivo Infection of Live Tissue with Oncolytic Viruses
Published on: June 25, 2011
[Viral infection--a diverse causative agent of cancer]
Pirita Pekkonen1, Päivi M Ojala
1Syöpäinstituutin säätiö, Helsingin Yliopisto, Bioteknikan Instituutti.
Abstract:
Viral infections are a common cause for the development of cancer. Most common among the cancer-inducing viruses are human papillomaviruses, which cause cervical cancer among other things. Cancer viruses aim to keep their host cells alive and simultaneously use their oncogenes to interfere with cellular phenomena such as proliferation and programmed cell death. The most effective way of preventing viral cancers is to reduce the frequency of cancer virus infections by using vaccinations and by intervening in high-risk behavior. In addition, the infections must be detected and treated in advance of cancer development.
Insights
Viral infections, like human papillomaviruses, can cause cancer by disrupting cell growth and death. Prevention through vaccination and early detection are key to combating these oncogenic viruses.
Area of Science:
- Oncology
- Virology
- Cell Biology
Context:
- Viral infections are a significant factor in human cancer development.
- Human papillomaviruses (HPVs) are a primary cause of various cancers, notably cervical cancer.
- Cancer viruses manipulate host cell processes, including proliferation and apoptosis, to ensure their survival and promote tumorigenesis.
Purpose:
- To elucidate the mechanisms by which oncogenic viruses contribute to cancer.
- To highlight the importance of preventative measures against viral oncogenesis.
- To emphasize the necessity of early detection and treatment of viral infections to prevent cancer progression.
Summary:
- Oncogenic viruses interfere with critical cellular functions like proliferation and programmed cell death to facilitate cancer development.
- Human papillomaviruses are a leading example of viruses that induce cancer, particularly cervical cancer.
- Effective strategies include reducing infection rates via vaccination and behavioral interventions, alongside prompt diagnosis and treatment.
Impact:
- Understanding viral oncogenesis aids in developing targeted cancer prevention and treatment strategies.
- Public health initiatives focusing on vaccination and risk reduction can significantly decrease the incidence of viral-associated cancers.
- Early detection and management of viral infections are crucial for preventing the transition to malignancy.
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