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Measurement of Tissue Oxygenation Using Near-Infrared Spectroscopy in Patients Undergoing Hemodialysis
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Skin and plasma autofluorescence during hemodialysis: a pilot study
Reindert Graaff1, Stefan Arsov, Bernd Ramsauer
1Department of UMC Staff, Universities of Groningen, Groningen, The Netherlands.
Artificial Organs
|October 30, 2013
Summary
Skin autofluorescence, a marker of advanced glycation end products, did not change after hemodialysis. This suggests skin autofluorescence measurements are reliable throughout dialysis sessions.
Area of Science:
- Nephrology
- Biochemistry
- Medical Technology
Background:
- Skin autofluorescence (AF) indicates advanced glycation end product (AGE) accumulation.
- Elevated skin AF is a significant predictor of mortality in hemodialysis (HD) patients.
Purpose of the Study:
- To determine if skin AF levels change after a single hemodialysis session.
- To investigate the relationship between changes in skin AF and plasma AF post-hemodialysis.
Main Methods:
- Noninvasive measurement of skin AF using an AGE Reader before and after HD.
- Measurement of plasma AF at 460 nm (excitation at 370 nm) before and after HD.
- Study included 35 maintenance HD patients (median age 68 years).
Main Results:
- HD patients exhibited 65% higher skin AF than age-matched controls (P < 0.001).
- Plasma AF decreased by 14% (P < 0.001) post-HD.
- No significant change in skin AF was observed after a single HD session.
Conclusions:
- Skin AF levels remain stable during a single hemodialysis session.
- Changes in plasma AF during HD do not directly impact skin AF measurements.
- Skin AF can be reliably measured throughout the entire dialysis period.
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