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Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

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Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
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Modified-Release Drug Delivery Systems: Site-Targeted01:24

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Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
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Modified-Release Drug Delivery Systems: Stimuli-Activated01:30

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Stimuli-activated drug delivery systems are designed to release drugs in response to specific physical, chemical, or biological stimuli. These systems often utilize hydrogels—three-dimensional, hydrophilic polymer networks capable of swelling in aqueous environments and retaining significant fluid volumes. Upon exposure to particular stimuli, these hydrogels undergo structural transitions that allow the embedded drug to be released. Due to this adaptive behavior, such systems are also...
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The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
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Modified-release dosage forms are designed to address the limitations of drugs with short biological half-lives. These forms maintain stable therapeutic drug concentrations over extended periods, reducing the need for frequent dosing. A consistent drug level helps minimize peak-trough fluctuations, which can reduce adverse effects, lower the risk of drug resistance, and improve overall treatment effectiveness.One common type of modified-release form is the extended-release (ER) formulation. ER...
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Conventional oral drug products, termed immediate-release (IR) formulations, are engineered to promptly release their active pharmaceutical ingredient (API) upon ingestion, typically in tablets or capsules. This rapid release often results in swift drug absorption and consequent pharmacodynamic effects, although the timing and intensity can vary depending on the drug's properties. Prodrugs within these formulations require metabolic conversion to activate their pharmacodynamic effects,...
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Uptake of New Lipid-coated Nanoparticles Containing Falcarindiol by Human Mesenchymal Stem Cells
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Electrosprayed core-shell polymer-lipid nanoparticles for active component delivery.

Megdi Eltayeb1, Eleanor Stride, Mohan Edirisinghe

  • 1Department of Mechanical Engineering, University College London, Torrington Place, London WC1E 7JE, UK.

Nanotechnology
|October 30, 2013
PubMed
Summary
This summary is machine-generated.

Electrohydrodynamic techniques efficiently produce core-shell polymer-lipid nanoparticles in one step. These stable, monodisperse nanoparticles are suitable for encapsulating active components for healthcare applications.

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Area of Science:

  • Materials Science
  • Nanotechnology
  • Biomedical Engineering

Background:

  • Producing reproducible, monodisperse nanoparticles with minimal steps is challenging for healthcare.
  • Multicomponent nanoparticles require precise control over structure and size.

Purpose of the Study:

  • To utilize electrohydrodynamic (EHD) techniques for single-step synthesis of core-shell polymer-lipid nanoparticles.
  • To achieve tunable nanoparticle sizes and narrow size distributions.
  • To evaluate the stabilization and encapsulation properties of the lipid shell.

Main Methods:

  • Employing electrohydrodynamic (EHD) techniques for nanoparticle fabrication.
  • Utilizing a hydrophilic core and a lipid shell (stearic acid).
  • Characterizing nanoparticle structure and properties using transmission electron microscopy and differential scanning calorimetry.

Main Results:

  • Reproducible manufacturing of core-shell nanoparticles with tunable sizes (30-90 nm) and narrow size distribution.
  • Demonstrated stabilization against collapse and aggregation by the lipid component.
  • Improved entrapment of active components (vanillin, ethylmaltol, maltol) within the nanoparticles.

Conclusions:

  • EHD is an effective single-step method for producing stable, monodisperse core-shell polymer-lipid nanoparticles.
  • The lipid shell enhances nanoparticle stability and active component encapsulation efficiency.
  • These nanoparticles show promise for various healthcare applications requiring controlled delivery.