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Updated: May 6, 2026

Quantitative Analysis of Mitochondria-Associated Endoplasmic Reticulum Membrane (MAM) Stabilization in a Neural Model of Alzheimer's Disease (AD)
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Memantine - neuroprotective drug in aging brain

Dominika Karolczak1, Emilia Sawicka, Jolanta Dorszewska

  • 1Andrzej Marszałek, MD, PhD, Collegium Medicum Nicolaus Copernicus University, Department of Clinical Pathomorphology, M. Skłodowskiej-Curie 9, 85-094 Bydgoszcz, tel. +48 52 5854200, fax +48 52 5854049,

Polish Journal of Pathology : Official Journal of the Polish Society of Pathologists
|October 30, 2013
PubMed
Summary

Aging brains show reduced caspase activity, a key part of programmed cell death (apoptosis). Memantine treatment increased active caspase-3 and caspase-9, suggesting a neuroprotective effect in aging rats.

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