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High serum vaspin concentrations in patients with ulcerative colitis
Tomohito Morisaki1, Fuminao Takeshima, Hiroko Fukuda
1Department of Gastroenterology and Hepatology, Graduate School of Biomedical Sciences, Nagasaki University, 1-7-1, Sakamoto, Nagasaki, 852-8501, Japan.
Digestive Diseases and Sciences
|October 30, 2013
Summary
Serum vaspin levels are elevated in ulcerative colitis (UC) patients and increase after remission. This suggests vaspin may help diagnose UC and monitor disease activity in inflammatory bowel disease (IBD).
Area of Science:
- Immunology and Inflammation Research
- Gastroenterology and Digestive Diseases
- Endocrinology and Metabolism
Background:
- Adipocytokines regulate energy balance, immune responses, and inflammation.
- Vaspin is a newly identified adipocytokine with potential anti-inflammatory properties.
Purpose of the Study:
- To investigate serum vaspin levels in inflammatory bowel disease (IBD), specifically Crohn's disease (CD) and ulcerative colitis (UC).
- To explore associations between serum vaspin and IBD disease course.
- To determine the intestinal localization of vaspin in IBD patients.
Main Methods:
- Serum samples collected from 30 CD patients, 33 UC patients, and 26 healthy controls.
- Enzyme-linked immunosorbent assays (ELISA) used to quantify serum vaspin concentrations.
- Immunohistochemical staining performed on intestinal tissues from IBD patients to assess vaspin localization.
Main Results:
- Serum vaspin concentrations were significantly higher in UC patients compared to CD patients and controls (p < 0.01).
- No significant difference in serum vaspin levels was observed between CD patients and controls, or between active and inactive IBD.
- Serum vaspin levels increased in most UC patients following remission induction. Vaspin was localized to mesenteric adipocytes, not intestinal epithelial or inflammatory cells.
Conclusions:
- Elevated serum vaspin concentrations in UC patients, particularly the increase post-remission, suggest its potential role in UC.
- Vaspin may serve as an auxiliary diagnostic marker for ulcerative colitis.
- Serum vaspin levels could be a useful indicator for assessing disease activity in UC patients.
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