Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Filaggrins].

H Hintner

    Der Hautarzt; Zeitschrift Fur Dermatologie, Venerologie, Und Verwandte Gebiete
    |November 1, 1985
    PubMed
    Summary
    This summary is machine-generated.

    Filaggrins are histidine-rich proteins crucial for keratin formation in the epidermis. Their breakdown yields compounds like urocanic acid and amino acids, vital for skin hydration and barrier function.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    [Diseases of the oral cavity].

    Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete·2012
    Same author

    Seven novel mutations in the ATP2A2 gene of Austrian patients with Darier's disease.

    Archives of dermatological research·2011
    Same author

    Role of immunofluorescence microscopy in dermatology.

    Giornale italiano di dermatologia e venereologia : organo ufficiale, Societa italiana di dermatologia e sifilografia·2011
    Same author

    [Immunofluorescence mapping for diagnosis of congenital epidermolysis bullosa].

    Actas dermo-sifiliograficas·2010
    Same author

    Cytokeratin 8 interacts with clumping factor B: a new possible virulence factor target.

    Microbiology (Reading, England)·2010
    Same author

    Nosocomial Staphylococcal scalded skin syndrome caused by intra-articular injection.

    Journal of the European Academy of Dermatology and Venereology : JEADV·2010
    Same journal

    Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete·2022
    Same journal

    [Viral infections of the skin].

    Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete·2022
    Same journal

    [Viral exanthems in children].

    Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete·2022
    Same journal

    [Erratum to: Digital health applications and data protection].

    Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete·2022
    Same journal

    [Virus-induced exanthems in returning travellers].

    Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete·2022
    Same journal

    [Venous ulcus cruris-Surgical treatment].

    Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete·2022
    See all related articles

    Area of Science:

    • Dermatology and protein biochemistry.

    Background:

    • Histidine-rich proteins, termed filaggrins, function as interfilamentous matrix proteins in epidermal keratin formation.
    • Filaggrins aggregate reconstituted keratin filaments into macrofibrils, mimicking the natural ultrastructural keratin pattern.

    Purpose of the Study:

    • To elucidate the role of filaggrins and their metabolic products in epidermal differentiation and skin physiology.
    • To understand the implications of altered filaggrin metabolism in pathological skin conditions.

    Main Methods:

    • The study focuses on the biochemical and functional roles of filaggrins and their precursors, profilaggrins.
    • Analysis of the metabolic breakdown products of filaggrins and their physiological significance.

    Main Results:

    • Filaggrins originate from high molecular weight profilaggrins synthesized in keratohyaline granules.

    Related Experiment Videos

  • Rapid breakdown of profilaggrins into filaggrins occurs during the transition of granular cells to corneocytes.
  • Further filaggrin metabolism produces urocanic acid (a potential sunscreen) and free amino acids (contributing to skin hydration and barrier function).

    • Conclusions:

    • Filaggrin metabolism is integral to epidermal differentiation and the maintenance of skin barrier function.
    • Alterations in filaggrin metabolism are linked to various skin pathologies, suggesting a role in disturbed epidermal differentiation.