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Comparative evaluation of single and bilayered lamotrigine floating tablets
Pk Lakshmi1, M Sridhar, B Shruthi
1Department of Pharmaceutics, G Pulla Reddy College of Pharmacy, Mehdipatnam, Hyderabad, Andhra Pradesh, India.
This study developed lamotrigine (LM) floating tablets for improved gastroretention. Single-layered tablets offer a cost-effective and reproducible alternative to bilayered designs for controlled drug release.
Area of Science:
- Pharmaceutical Sciences
- Drug Delivery Systems
Background:
- Floating tablets offer prolonged gastric residence time, enhancing drug absorption.
- Lamotrigine (LM) is an antiepileptic drug requiring controlled release for optimal efficacy.
Purpose of the Study:
- To prepare and characterize lamotrigine (LM) bilayered and single-layered floating tablets.
- To compare the in vitro release profiles and buoyancy characteristics of LM floating tablets.
Main Methods:
- Tablets were prepared using direct compression with hydrophilic polymers (HPMC K4M, HPC-M) and sodium bicarbonate.
- Evaluation included physicochemical properties, floating lag time (FLT), floating duration, and in vitro drug release.
- Drug-polymer interactions were assessed using FTIR and DSC.
Main Results:
- Optimized formulations exhibited FLT within 3 minutes and sustained buoyancy for up to 16 hours.
- Zero-order kinetics and Fickian diffusion characterized the drug release from optimized tablets.
- No significant difference in release profiles was observed between single-layered and bilayered tablets.
Conclusions:
- Hydroxypropyl cellulose-M proved effective for achieving prolonged buoyancy in LM floating tablets.
- Single-layered floating tablets are a viable, economical, and reproducible option for large-scale production.
- The study confirms the feasibility of developing bilayered gastroretentive floating tablets for controlled LM release.
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