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New phenanthrene glycosides from Dioscorea opposita
Ken Yu-Zhong Zheng1, Zhen-Xia Zhang, Wenliang Zhou
1a The School of Life Science, Sun Yat-Sen University , Guangzhou , 510275 , China.
Abstract:
Two new phenanthrene glycosides, dioscopposide A and dioscopposide B (1 and 2), were isolated from the rhizomes of Dioscorea opposita. Their structures were determined primarily on the basis of 1D and 2D NMR techniques, MS studies, and chemical methods. All the isolates were evaluated for their inhibitory effects on the lipopolysaccharide-induced nitric oxide production using murine macrophage RAW 264.7 cells. The IC50 values of dioscopposide A and dioscopposide B were 5.8 and 7.2 μM, respectively.
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