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Updated: May 6, 2026

Training Synesthetic Letter-color Associations by Reading in Color
Published on: February 20, 2014
Grapheme-color and tone-color synesthesia is associated with structural brain changes in visual regions implicated in
Michael J Banissy1, Lauren Stewart, Neil G Muggleton
1a UCL Institute of Cognitive Neuroscience , University College London , London , UK.
Abstract:
Synesthesia is a rare condition in which stimulation in one modality leads to a secondary experience in another sensory modality. Varying accounts attribute the condition to either neuroanatomical differences between the synesthetes and non-synesthetes or functional differences in how sensory brain regions interact. This study employed voxel-based morphometry to examine whether synesthetes who experience both grapheme-color and tone-color synesthesia as their evoked sensation show neuroanatomical differences in gray matter volume compared to non-synesthetes. We observed that synesthetes showed an increase in gray matter volume in left posterior fusiform gyrus (FG), but a concomitant decrease in anterior regions of left FG and left MT/V5. These findings imply that synesthesia for color is linked to neuroanatomical changes between adjacent regions of the visual system.
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