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Related Concept Videos

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Procedures for Kidney StonesMedical intervention is necessary when kidney stones or renal calculi are too large to pass spontaneously (typically greater than 5 millimeters) when stones are accompanied by symptomatic infection (such as fever or pyelonephritis), when they impair kidney function, or when they cause persistent symptoms like severe pain, nausea, or urinary retention. Additionally, patients with only one kidney or those who cannot be treated with medical management also require...
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Related Experiment Video

Updated: May 6, 2026

Photoselective Vaporesection of the Prostate via an End-firing Lithium Triborate Crystal Laser
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Retrograde endoscopic lithotripsy using the innovative nanosecond electropulse method.

Alexander Gudkov1, Vacheslav Boshchenko, Alexander Petlin

  • 1Department of Urology, Siberian State Medical University, Lenin Avenue #4, HC SSMU, Tomsk, 634050 Russia.

Springerplus
|October 31, 2013
PubMed
Summary

Nanosecond electropulse lithotripsy (NEPL) offers a safe and effective endoscopic treatment for urinary stones. This novel method uses electric pulses for fast stone disintegration with a 96% stone-free rate and minimal complications.

Keywords:
Endoscopic lithotripsyNanosecond electropulse lithotripsyNephrolithiasisUrolithiasis

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Area of Science:

  • Urology
  • Minimally Invasive Surgery
  • Biophysics

Background:

  • Urinary tract stones pose a significant clinical challenge.
  • Current lithotripsy methods have limitations in efficacy and safety.
  • Endoscopic stone treatment requires precise and effective fragmentation techniques.

Purpose of the Study:

  • To evaluate the safety and efficacy of a novel nanosecond electropulse lithotripsy (NEPL) method.
  • To assess NEPL for endoscopic treatment of urinary stones throughout the urinary tract.
  • To determine the feasibility of NEPL using semi-rigid and flexible endoscopes.

Main Methods:

  • A prospective, single-arm study involving 879 patients (aged 19-88) with renal, ureter, and bladder calculi.
  • Retrograde transurethral treatments utilizing flexible probes delivering nanosecond high voltage electric pulses.
  • Recording of auxiliary treatments and adverse events, with statistical analysis using SPSS software.

Main Results:

  • NEPL demonstrated technical feasibility for stones in the kidney, UPJ, ureter, and bladder.
  • Effective stone disintegration was achieved with a few dozen pulses, causing minimal migration.
  • An overall stone-free rate of 96% was achieved with an average procedure time of 45±28 minutes.

Conclusions:

  • NEPL is an efficient and safe endoscopic method for urinary stone disintegration across the urinary tract.
  • Intraoperative complications are comparable to existing lithotripsy methods.
  • Key advantages include cost-effectiveness, rapid fragmentation, tissue safety, and suitability for lower pole stones via flexible ureterorenoscopes.