Related Experiment Video
Updated: May 6, 2026

Formation of Dispersible Taohong Siwu Tablets
Published on: February 3, 2023
Effect of repeated compaction of tablets on tablet properties and work of compaction using an instrumented laboratory
Michael John Desmond Gamlen1, Luigi G Martini, Kais G Al Obaidy
1Gamlen Tableting Ltd , Biocity Nottingham, Nottingham , UK .
Abstract:
The repeated compaction of Avicel PH101, dicalcium phosphate dihydrate (DCP) powder, 50:50 DCP/Avicel PH101 and Starch 1500 was studied using an instrumented laboratory tablet press which measures upper punch force, punch displacement and ejection force and operates using a V-shaped compression profile. The measurement of work compaction was demonstrated, and the test materials were ranked in order of compaction behaviour Avicel PH101 > DCP/Avicel PH101 > Starch > DCP. The behaviour of the DCP/Avicel PH101 mixture was distinctly non-linear compared with the pure components. Repeated compaction and precompression had no effect on the tensile fracture strength of Avicel PH101 tablets, although small effects on friability and disintegration time were seen. Repeated compaction and precompression reduced the tensile strength and the increased disintegration time of the DCP tablets, but improved the strength and friability of Starch 1500 tablets. Based on the data reported, routine laboratory measurement of tablet work of compaction may have potential as a critical quality attribute of a powder blend for compression. The instrumented press was suitable for student use with minimal supervisor input.
More Related Videos
10:36Stress Distribution During Cold Compression of Rocks and Mineral Aggregates Using Synchrotron-based X-Ray Diffraction
Published on: May 20, 2018
10:27A Uniaxial Compression Experiment with CO2-Bearing Coal Using a Visualized and Constant-Volume Gas-Solid Coupling Test System
Published on: June 12, 2019
Related Concept Videos
Factors Influencing Drug Absorption: Pharmaceutical Parameters
In Vitro Drug Dissolution: Compendial Testing Models I
Formulation and Manufacturing Process: Physical Attributes of Generic Tablets and Capsules
Compacting Factor test
The procedure begins by placing concrete into the upper hopper without any compaction. Once filled, the bottom door of this hopper is opened,...
In Vitro Drug Dissolution: Compendial Testing Models II
Pharmaceutical Alternatives: Polymorphic Form-Related and Particle Size-Related Therapeutic Nonequivalence