Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Hypodermis01:02

Hypodermis

7.8K
The hypodermis (the subcutaneous layer or superficial fascia) is present directly below the dermis. It connects the skin to the underlying fascia (fibrous tissue) of the bones and muscles. It is not strictly a part of the skin, although the border between the hypodermis and dermis can be difficult to distinguish. The hypodermis consists of well-vascularized, loose, areolar connective tissue and adipose tissue, which functions as a mode of fat storage and provides insulation and cushioning for...
7.8K
Introduction to Lymphatic and Immune System01:23

Introduction to Lymphatic and Immune System

12.2K
Immunity is a crucial biological concept about our body's inherent capacity to prevent infections and diseases. A complex network of cells and tissues collectively known as the immune system facilitates this natural defense mechanism. The immune system plays an integral role in maintaining our health and well-being, shielding us from potential health threats.
The immune responses can be categorized into two types: innate and adaptive. Innate immunity comprises nonspecific defenses we are born...
12.2K
Functions of the Lymphatic and Immune System01:28

Functions of the Lymphatic and Immune System

6.5K
The lymphatic system plays a crucial role in bolstering our immune system. It consists of a network of lymphoid organs, lymph, and lymphatic vessels that provide structural and functional support in safeguarding the body against pathogens such as viruses and bacteria.
The primary lymphoid organs, including the bone marrow and the thymus, serve as the maturation sites for lymphocytes. Secondary lymphoid organs, like the mucosa-associated lymphoid tissue, activate these lymphocytes and serve as...
6.5K
Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

65.0K
Overview
65.0K
What is the Immune System?01:38

What is the Immune System?

100.3K
Overview
100.3K
Chronic Inflammation: Introduction01:12

Chronic Inflammation: Introduction

51
Chronic inflammation is a prolonged, dysregulated immune response that persists for weeks to years when the inciting stimulus is difficult to eradicate or when self‑antigens drive ongoing reactivity. Morphologically, it is defined by mononuclear cell infiltration, progressive tissue destruction, and concurrent attempts at healing via angiogenesis and fibrosis. Compared with acute inflammation, edema is less prominent while cellular infiltration predominates; triggers include persistent...
51

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Vitamin D3 and Body Composition Association with Graft Function in Long-Term Kidney Transplant Recipients.

International journal of molecular sciences·2026
Same author

The Role of Microbiome and Diet on Disease Activity and Immune-Inflammatory Status in Rheumatoid Arthritis.

Nutrients·2026
Same author

Nutritional Knowledge, Dietary Habits, and Nutritional Status of Patients with Chronic Kidney Disease According to Disease Stage.

Nutrients·2026
Same author

Nutritional Status and Dietary Assessment in Kidney Transplant Recipients.

Nutrients·2026
Same author

Low calcium intake from diet and supplements in a group of Polish patients with SLE - an additional risk for osteoporotic fractures?

Acta biochimica Polonica·2026
Same author

Quality of Life of Colorectal Cancer Patients Treated with Chemotherapy.

Nutrients·2026

Related Experiment Video

Updated: May 6, 2026

Isolation of Adipose Tissue Immune Cells
07:09

Isolation of Adipose Tissue Immune Cells

Published on: May 22, 2013

36.0K

Complex interaction between the immune system and adipose tissue (Review).

Sylwia Małgorzewicz1, Jolanta Anna Dardzińska, Maria Gnacińska

  • 1Department of Clinical Nutrition, Medical University of Gdansk, 80-211 Gdańsk, Poland.

International Journal of Molecular Medicine
|November 1, 2013
PubMed
Summary

Obesity impacts immune cells and function. Metformin, which activates 5-adenosine monophosphate (AMP)-activated kinase (AMPK), may improve obesity treatment alongside lifestyle changes.

More Related Videos

Characterization of Immune Cells in Human Adipose Tissue by Using Flow Cytometry
07:32

Characterization of Immune Cells in Human Adipose Tissue by Using Flow Cytometry

Published on: March 6, 2018

20.9K
Isolation of Viable Adipocytes and Stromal Vascular Fraction from Human Visceral Adipose Tissue Suitable for RNA Analysis and Macrophage Phenotyping
06:22

Isolation of Viable Adipocytes and Stromal Vascular Fraction from Human Visceral Adipose Tissue Suitable for RNA Analysis and Macrophage Phenotyping

Published on: October 27, 2020

4.4K

Related Experiment Videos

Last Updated: May 6, 2026

Isolation of Adipose Tissue Immune Cells
07:09

Isolation of Adipose Tissue Immune Cells

Published on: May 22, 2013

36.0K
Characterization of Immune Cells in Human Adipose Tissue by Using Flow Cytometry
07:32

Characterization of Immune Cells in Human Adipose Tissue by Using Flow Cytometry

Published on: March 6, 2018

20.9K
Isolation of Viable Adipocytes and Stromal Vascular Fraction from Human Visceral Adipose Tissue Suitable for RNA Analysis and Macrophage Phenotyping
06:22

Isolation of Viable Adipocytes and Stromal Vascular Fraction from Human Visceral Adipose Tissue Suitable for RNA Analysis and Macrophage Phenotyping

Published on: October 27, 2020

4.4K

Area of Science:

  • Immunology
  • Metabolism
  • Pharmacology

Background:

  • Obesity, characterized by positive energy balance, disrupts immune cell function via altered intracellular pathways.
  • Lifestyle factors like calorie intake significantly influence the interplay between obesity and the immune system.

Purpose of the Study:

  • To review the relationship between obesity, the immune system, and lifestyle modifications.
  • To explore the potential of pharmacological interventions, such as metformin, in managing obesity-related immune dysregulation.

Main Methods:

  • Literature review of studies investigating obesity, immune response, and therapeutic strategies.
  • Analysis of research on the effects of calorie intake and energy expenditure on immune function.
  • Examination of the role of 5-adenosine monophosphate (AMP)-activated kinase (AMPK) in obesity and related pathways.

Main Results:

  • Positive energy balance in obesity negatively affects immune cells and their functions.
  • Metformin enhances 5-adenosine monophosphate (AMP)-activated kinase (AMPK) activity, a known target in diabetes and obesity treatment.
  • Lifestyle interventions (diet, exercise) are crucial but may be enhanced by AMPK-targeting drugs.

Conclusions:

  • Modulating 5-adenosine monophosphate (AMP)-activated kinase (AMPK) activity presents a promising therapeutic avenue for obesity.
  • Future research should focus on targeting specific receptors or immune cells in adipose tissue for novel obesity treatments.