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Related Experiment Videos

[Hyperthermic perfusion therapy using peplomycin for bladder cancer].

K Nakajima, H Hisazumi, T Misaki

    Hinyokika Kiyo. Acta Urologica Japonica
    |September 1, 1985
    PubMed
    Summary

    Hyperthermic intravesical perfusion with peplomycin showed limited efficacy for bladder tumors, with only a few patients experiencing tumor regression. The treatment caused significant bladder discomfort but did not lead to acute pyelonephritis.

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    Radiofrequency capacitive hyperthermia for superficial malignant-tumors.

    International journal of oncology·2011

    Area of Science:

    • Oncology
    • Urology
    • Hyperthermia Therapy

    Context:

    • Superficial and deep bladder tumors present a significant clinical challenge.
    • Current treatment options for bladder cancer have limitations and side effects.
    • Hyperthermic intravesical perfusion is an emerging therapeutic modality.

    Purpose:

    • To evaluate the therapeutic efficacy and safety of hyperthermic intravesical perfusion therapy using peplomycin for bladder tumors.

    Summary:

    • Eighteen patients with superficial bladder tumors and two with deep bladder tumors underwent hyperthermic intravesical perfusion with peplomycin (40 µg/ml) at 43°C for 2-3 hours.
    • Therapeutic efficacy was assessed via cystoscopy, ultrasonography, and CT scans.
    • Complete tumor regression was observed in one patient, partial regression in three, and no regression in twelve patients with superficial tumors. No patients developed acute pyelonephritis, though bladder discomfort was common.

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    Impact:

    • Hyperthermic intravesical perfusion with peplomycin demonstrated limited efficacy in achieving tumor regression for bladder tumors.
    • The therapy was associated with significant patient-reported bladder discomfort.
    • Further research is needed to optimize this treatment modality for bladder cancer.