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Updated: May 6, 2026
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A High-Throughput Multiplexed Screening for Type 1 Diabetes, Celiac Diseases, and COVID-19
Published on: July 5, 2022
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Italian risk factor-based screening for gestational diabetes.
F Corrado1, B Pintaudi, G Di Vieste
1Department of Obstetrics & Gynecology and.
Summary
Selective screening for gestational diabetes identified 77% of cases, sparing over 40% of pregnant women from glucose testing. However, some cases were missed, highlighting the need for further clinical impact analysis.
Area of Science:
- Obstetrics and Gynecology
- Endocrinology
- Public Health
Background:
- Debate exists regarding universal vs. risk-based screening for gestational diabetes mellitus (GDM).
- Current guidelines from IADPSG/ADA recommend universal screening, while NICE/Italian National Institute of Health suggest selective screening.
- Comparing these approaches is crucial for optimizing diagnostic strategies.
Purpose of the Study:
- To compare the diagnostic yield of universal screening (IADPSG/ADA) versus a modified selective screening (NICE/Italian National Institute of Health) for gestational diabetes in a specific population.
- To evaluate the predictive value of risk factors used in selective screening.
- To assess the potential for reducing oral glucose tolerance tests (OGTT) with selective screening.
Main Methods:
- Retrospective study of 1015 pregnant women from May 2010 to October 2011.
- Screening for GDM using IADPSG criteria, with registration of risk factors.
- Comparison of universal screening results with a modified selective screening protocol.
- Analysis of risk factor predictive value, including maternal age, prepregnancy BMI, and nulliparity.
Main Results:
- 113 (11%) women were diagnosed with GDM.
- The modified selective screening identified 77% of GDM cases.
- 26 (23%) of GDM cases would have been missed by selective screening.
- Maternal age ≥35 years showed no significant predictive role (OR: 0.98).
- Prepregnancy BMI and nulliparity were predictive in the low-risk group.
- Selective screening spared over 40% of women from OGTT.
Conclusions:
- The modified selective risk-based screening strategy effectively identifies a majority of GDM cases while significantly reducing the need for OGTT.
- While selective screening offers efficiency, a notable percentage of GDM cases may be missed, necessitating further investigation into their clinical impact.
- Further research on the outcomes of 'missed' GDM cases is warranted to fully assess the clinical implications of selective screening strategies.
Keywords:
Gestational diabetes mellitusperinatal outcomerisk factorselective screeninguniversal screeningMore Related Videos
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