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Acitretin in dermatology.

Rashmi Sarkar1, Shikha Chugh, Vijay K Garg

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|November 2, 2013
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Summary
This summary is machine-generated.

Acitretin, a synthetic retinoid, is a valuable treatment for various skin conditions like psoriasis and nonmelanoma skin cancers due to its anti-inflammatory and anti-proliferative effects. This review covers its efficacy, side effects, and safe usage guidelines.

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Area of Science:

  • Dermatology
  • Pharmacology

Background:

  • Acitretin, a synthetic retinoid, has largely replaced etretinate due to improved pharmacokinetics.
  • It has been used for two decades in treating hyperkeratotic and inflammatory dermatoses and nonmelanoma skin cancers.

Purpose of the Study:

  • To review the evidence-based efficacy and side-effect profile of acitretin.
  • To discuss the approved and off-label uses of acitretin.
  • To summarize contraindications and precautions for acitretin prescription.

Main Methods:

  • Literature review of acitretin's properties and clinical applications.
  • Analysis of its therapeutic effects and adverse events.

Main Results:

  • Acitretin is effective as monotherapy or in combination for hyperkeratotic disorders.
  • It is an established second-line treatment for psoriasis, acting via antikeratinizing, anti-inflammatory, and antiproliferative mechanisms.
  • Its antineoplastic properties support cancer prophylaxis.

Conclusions:

  • Acitretin is a versatile therapeutic agent for various dermatological conditions.
  • Its use requires careful consideration of teratogenic potential and other adverse effects like mucocutaneous issues and hepatotoxicity.