Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Autism Spectrum Disorder01:19

Autism Spectrum Disorder

2.0K
Autism spectrum disorder (ASD) is a neurodevelopmental condition marked by persistent deficits in social communication and interaction alongside restrictive and repetitive behaviors or interests. ASD is sometimes accompanied by intellectual impairment.
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.
2.0K
Modeling in Therapy01:26

Modeling in Therapy

826
Modeling, a key technique in therapy, uses observational learning to help clients acquire and practice new skills by watching therapists demonstrate desired behaviors. This approach, rooted in Albert Bandura's concept of vicarious learning, plays a significant role in therapeutic interventions for various psychological conditions, including social anxiety, ADHD, and depression.
Participant Modeling
Participant modeling involves therapists demonstrating calm and effective behaviors in...
826
Gut-Brain Axis01:22

Gut-Brain Axis

252
The gut–brain axis is a bidirectional communication system that connects the gastrointestinal tract and the brain. This interaction is mediated through multiple pathways, including the vagus nerve, hormonal signals, immune responses, and chemical messengers produced by gut microbes.Microbial Contributions to Brain FunctionGut microbiota contributes significantly to brain function by producing neuroactive compounds. These include neuroactive compounds that influence neurotransmitters such...
252

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Generalised random tessellation stratified sampling over auxiliary spaces.

Journal of applied statistics·2025
Same author

Investigating the Dynamics of Salmonella Contamination During Commercial Pork Harvest Using Qualitative and Quantitative Detection Methods.

Journal of food protection·2025
Same author

Investigating drug trends among people who inject drugs: Temporal, geographical and operational analyses of used syringes in Sydney, Australia.

The International journal on drug policy·2025
Same author

The gastrointestinal tract microbiome of Holstein × Angus cross cattle is negatively impacted by the pre-harvest process.

Applied and environmental microbiology·2025
Same author

Abstracts of presentations to the Annual Meetings of the Canadian Society of Colon and Rectal Surgeons Canadian Association of General Surgeons Canadian Association of Thoracic Surgeons: Canadian Surgery Forum, Toronto, Ont., September 6-9, 2007.

Canadian journal of surgery. Journal canadien de chirurgie·2023
Same author

Effect of season on weaned piglet mortality during transport greater than 8 h under Canadian conditions.

Preventive veterinary medicine·2023
Same journal

Within-subject alterations in CSF and blood flow dynamics following rhythm-control intervention in atrial fibrillation: An exploratory multimodal MRI study.

NeuroImage. Clinical·2026
Same journal

Diffusion MRI of white matter alterations in chronic traumatic brain injury: a systematic review and meta-analysis.

NeuroImage. Clinical·2026
Same journal

Decoding functional changes in the brain following ischemic stroke: a multimodal feature approach integrating fNIRS with machine learning and deep learning.

NeuroImage. Clinical·2026
Same journal

Structural brain alterations in chronic primary pain: a multimodal MRI study.

NeuroImage. Clinical·2026
Same journal

Using functional MRI neurofeedback to modulate self-blame in major depressive disorder: A pilot study.

NeuroImage. Clinical·2026
Same journal

Language network reorganization in temporal lobe epilepsy: insights from task-based functional MRI.

NeuroImage. Clinical·2026
See all related articles

Related Experiment Video

Updated: May 6, 2026

Probing the Brain in Autism Using fMRI and Diffusion Tensor Imaging
12:21

Probing the Brain in Autism Using fMRI and Diffusion Tensor Imaging

Published on: September 12, 2011

24.5K

Altered functional and structural brain network organization in autism.

J D Rudie1, J A Brown, D Beck-Pancer

  • 1Brain Mapping Center, UCLA, Los Angeles, CA, USA ; Interdepartmental Neuroscience Program, UCLA, Los Angeles, CA, USA ; David Geffen School of Medicine, UCLA, Los Angeles, CA, USA.

Neuroimage. Clinical
|November 2, 2013
PubMed
Summary
This summary is machine-generated.

Autism spectrum disorder (ASD) is linked to altered brain connectivity. This study reveals reduced functional integration and segregation in ASD, impacting network efficiency and correlating with symptom severity.

Keywords:
Autism spectrum disordersBrain networksDiffusion tensor imagingGraph theoryResting-state functional connectivity

More Related Videos

Dynamic Clamp Methods to Investigate Impaired Neuronal Excitability Associated with Autism
08:44

Dynamic Clamp Methods to Investigate Impaired Neuronal Excitability Associated with Autism

Published on: October 17, 2025

865
Comparing Eye-tracking Data of Children with High-functioning ASD, Comorbid ADHD, and of a Control Watching Social Videos
05:32

Comparing Eye-tracking Data of Children with High-functioning ASD, Comorbid ADHD, and of a Control Watching Social Videos

Published on: December 7, 2018

8.5K

Related Experiment Videos

Last Updated: May 6, 2026

Probing the Brain in Autism Using fMRI and Diffusion Tensor Imaging
12:21

Probing the Brain in Autism Using fMRI and Diffusion Tensor Imaging

Published on: September 12, 2011

24.5K
Dynamic Clamp Methods to Investigate Impaired Neuronal Excitability Associated with Autism
08:44

Dynamic Clamp Methods to Investigate Impaired Neuronal Excitability Associated with Autism

Published on: October 17, 2025

865
Comparing Eye-tracking Data of Children with High-functioning ASD, Comorbid ADHD, and of a Control Watching Social Videos
05:32

Comparing Eye-tracking Data of Children with High-functioning ASD, Comorbid ADHD, and of a Control Watching Social Videos

Published on: December 7, 2018

8.5K

Area of Science:

  • Neuroscience
  • Developmental Neuroscience
  • Network Science

Background:

  • Autism spectrum disorder (ASD) is characterized by atypical brain connectivity, including underconnectivity in various regions and tracts.
  • Complex network analysis reveals the brain's modular, small-world organization, but network-level organization in ASD remains underexplored.

Purpose of the Study:

  • To investigate network-level brain organization in children and adolescents with ASD using resting-state functional MRI (rs-fMRI) and diffusion tensor MRI (dMRI).
  • To examine differences in functional and structural connectivity, modularity, and efficiency between individuals with ASD and typically developing (TD) controls.

Main Methods:

  • Resting-state fMRI data from 42 ASD and 37 TD individuals analyzed for functional connectivity.
  • Diffusion tensor MRI data from 51 ASD and 43 TD individuals used to generate structural networks.
  • Graph theoretical methods applied to assess network properties like modularity, clustering (local efficiency), and characteristic path length (global efficiency).

Main Results:

  • Individuals with ASD showed reduced short and long-range functional connectivity within systems (lower integration) and increased connectivity between systems (lower segregation), especially in default and visual networks.
  • ASD exhibited reduced network modularity and clustering but shorter path lengths (higher global efficiency) compared to TD individuals.
  • Structural networks in ASD had lower white matter integrity but more fibers; the balance of local and global efficiency was reduced, correlating with age and symptom severity.

Conclusions:

  • Brain network organization in ASD is characterized by altered functional integration and segregation, impacting both local and global network efficiency.
  • The findings highlight the utility of complex network modeling in understanding the neurobiological underpinnings of ASD.
  • Network-based analysis provides insights into the relationship between brain structure, function, age, and symptom severity in ASD.