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Related Concept Videos

Brain Imaging01:14

Brain Imaging

Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans),  magnetic resonance imaging (MRI),  functional magnetic resonance imaging (fMRI), and Transcranial Magnetic Stimulation (TMS).

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Structural brain alterations in chronic primary pain: a multimodal MRI study.

Salome Häuselmann1, Anna Wyss2, Nina Bischoff3

  • 1Psychosomatic Medicine, Department of Neurology, Inselspital, Bern University Hospital, University of Bern, Switzerland; Graduate School of Cellular and Biomedical Sciences (GCB), University of Bern, Switzerland; Translational Imaging Center (TIC), Swiss Institute for Translational and Entrepreneurial Medicine, Bern, Switzerland.

Neuroimage. Clinical
|June 25, 2026
PubMed
Summary
This summary is machine-generated.

Chronic primary pain (CPP) is linked to distinct brain structural changes, particularly in cortical folding patterns. These alterations in brain morphology may be associated with biopsychosocial factors like stress and childhood trauma.

Keywords:
Chronic primary painCortical thicknessFractal dimensionGyrificationStructural connectivitySulcal depthSurface-based morphometry

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Area of Science:

  • Neuroscience
  • Medical Imaging
  • Pain Research

Background:

  • Chronic primary pain (CPP) is a condition without a clear cause, marked by persistent pain, emotional distress, and functional impairment.
  • Pain chronification may involve structural brain changes.

Purpose of the Study:

  • To investigate cortical surface morphometry and structural connectivity in CPP patients.
  • To explore associations between brain alterations and biopsychosocial characteristics.

Main Methods:

  • MRI (T1-weighted, DWI) and psychometric assessments were used in 30 CPP patients and 30 healthy controls (HCs).
  • Surface-based morphometry (SBM) and diffusion-weighted imaging (DWI) were employed to analyze brain structure and connectivity.
  • Partial least squares correlation (PLSC) examined links between imaging data and biopsychosocial factors.

Main Results:

  • CPP patients exhibited altered cortical folding, including increased gyrification in the left prefrontal cortex and reduced sulcal depth in frontal and temporo-occipital regions.
  • No significant group differences in structural connectivity were found.
  • PLSC identified covariation between SBM patterns and biopsychosocial factors like stress and childhood trauma, particularly in HCs.

Conclusions:

  • Cortical surface morphology appears to be structurally altered in individuals with CPP.
  • Further longitudinal studies are needed to understand the dynamics of these brain changes in CPP.