Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Ionic channels in leukocytes.

E K Gallin

    Journal of Leukocyte Biology
    |March 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

    The patch clamp technique has advanced leukocyte electrophysiology, revealing various ionic channels in immune cells. Further research is needed to discover additional channels and their roles.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Translational careers.

    Science (New York, N.Y.)·2009
    Same author

    Ca2+-dependent production and release of IL-8 in human neutrophils.

    Journal of immunology (Baltimore, Md. : 1950)·1998
    Same author

    Modulation of K+ currents in monocytes by VCAM-1 and E-selectin on activated human endothelium.

    The American journal of physiology·1998
    Same author

    IKir regulation in murine macrophages: whole cell and perforated patch studies.

    The American journal of physiology·1994
    Same author

    Ionizing radiation increases endothelial and epithelial cell production of influenza virus and leukocyte adherence.

    Journal of immunology (Baltimore, Md. : 1950)·1994
    Same author

    Characterization of regulatory volume decrease in the THP-1 and HL-60 human myelocytic cell lines.

    Journal of cellular physiology·1994

    Area of Science:

    • Immunology
    • Cell Physiology
    • Electrophysiology

    Background:

    • Leukocyte electrophysiology has significantly advanced with the patch clamp technique.
    • Ionic channels play crucial roles in leukocyte function.
    • Previous research has identified several, but not all, ionic channels in leukocytes.

    Purpose of the Study:

    • To review known ionic channels in leukocytes.
    • To discuss the functional relevance of these channels.
    • To highlight the current state of research and future directions.

    Main Methods:

    • Literature review of electrophysiological and biochemical studies.
    • Focus on voltage- and ligand-gated ionic channels.
    • Exclusion of neutrophils and eosinophils from detailed characterization in this review.

    Related Experiment Videos

    Main Results:

    • Various ionic channels have been identified in different leukocyte types.
    • The functional relevance of these channels is increasingly understood.
    • The current list of identified channels is not exhaustive.

    Conclusions:

    • The field of leukocyte electrophysiology is rapidly expanding.
    • Many more ionic channels likely exist in leukocytes with undiscovered functions.
    • Continued research is essential to fully elucidate leukocyte ion channel biology.