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Correlation between CD14+CD16++ monocytes in peripheral blood and hypertriglyceridemia after allograft renal
1Department of Urology, Third Affiliated Hospital, Suzhou University, Changzhou, China, and Lund Universities, Lund, Sweden.
Insights
Peripheral CD14+CD16++ monocytes may indicate a higher risk of hypertriglyceridemia (HTG) in kidney transplant (KT) recipients. This finding offers insights into cardio-cerebrovascular disease risk factors post-transplantation.
Area of Science:
- Immunology
- Nephrology
- Cardiology
Background:
- Cardio-cerebrovascular diseases are leading causes of mortality in kidney transplant (KT) recipients.
- Hypertriglyceridemia (HTG), a common complication post-KT, significantly elevates this risk.
- Understanding inflammatory mechanisms is crucial for managing post-KT complications.
Purpose of the Study:
- To investigate the association between peripheral CD14+CD16++ monocytes and blood lipids in KT patients.
- To explore factors influencing hyperglycemia in KT recipients.
- To elucidate the role of inflammatory immune reactions in HTG post-KT.
Main Methods:
- Compared KT patients (n=60) with and without HTG to healthy controls (n=55).
- Quantified peripheral CD14+CD16++ monocyte proportions using flow cytometry.
- Measured biochemical indicators and correlated them with HTG status.
Main Results:
- A lower proportion of peripheral CD14+CD16++ monocytes was observed in KT recipients compared to controls (P < .05).
- The expression of CD14+CD16++ monocytes positively correlated with triglyceride levels in transplant recipients (R = 0.449, P = 0.008).
Conclusions:
- Peripheral blood CD14+CD16++ monocytes may serve as an independent risk factor for HTG after kidney transplantation.
- This finding highlights a potential biomarker for cardiovascular risk in KT patients.
Background:
Cardio-cerebrovascular diseases are key factors causing recipient the death after kidney transplantation (KT). Hypertriglyceridemia (HTG), a complication commonly occurring among KT patients, is a major risk factor for cardio-cerebrovascular diseases. The objective of this study was to examine the correlation between peripheral CD14+CD16++ monocytes in KT patients and blood lipids as well as factors affecting hyperglycemia, seeking to understand mechanisms of inflammatory immune reactions.
Methods:
KT patients (n = 60) were divided into subjects with HTG (n = 35) versus without HTG (n = 25). A cohort of healthy participants (55 cases) was divided into the cases without (n = 30) versus with HTG (n = 25). The proportion of peripheral CD14+CD16 ++ monocytes was determined using flow cytometry and hematology, and biochemical indicators were measured by conventional methods. We correlated HTG with these indicators.
Results:
The proportion of peripheral blood CD14+CD16++ monocytes among the renal transplant group was significantly lower (P < .05) than that of normal controls. The expression of CD14+CD16++ monocytes among transplant recipients positively correlated with triglycerides (R = 0.449 and R = 0.008, respectively).
Conclusion:
CD14+CD16++ mononcytes in peripheral blood may represent an independent risk factor for HTG after KT.
