Related Experiment Video
Updated: May 6, 2026
06:23
Diagnosis and Surgical Treatment of Human Brucellar Spondylodiscitis
Published on: May 23, 2021
4.8K
Update on juvenile spondyloarthritis
Anusha Ramanathan1, Hemalatha Srinivasalu, Robert A Colbert
1Division of Rheumatology, Keck School of Medicine of USC, Children's Hospital of Los Angeles, 4650 Sunset Boulevard, MS#60, Los Angeles, CA 90027, USA.
Rheumatic Diseases Clinics of North America
|November 5, 2013
Summary
Spondyloarthritis (SpA) presents differently in children versus adults, impacting disease course and outcomes. Understanding these age-related differences is crucial for advancing SpA research and treatment.
Area of Science:
- Rheumatology
- Pediatric Rheumatology
- Immunogenetics
Background:
- Spondyloarthritis (SpA) is a spectrum of inflammatory diseases sharing clinical and genetic features.
- Current adult SpA classifications may not fully capture pediatric presentations.
- Pediatric-onset SpA represents a continuum of adult disease but with distinct characteristics.
Purpose of the Study:
- To highlight age-dependent differences in SpA presentation and outcomes.
- To review current knowledge on SpA genetics and pathogenesis.
- To identify key unmet needs in SpA research.
Main Methods:
- Literature review and synthesis of existing SpA research.
- Comparative analysis of pediatric versus adult SpA cohorts.
- Discussion of genetic and pathogenic mechanisms.
Main Results:
- Significant variations exist in how SpA manifests based on age at onset.
- Genetics and pathogenesis research continues to evolve.
- Specific research gaps hinder optimal management of pediatric SpA.
Conclusions:
- Age at onset is a critical factor influencing SpA clinical course and prognosis.
- Further research is needed to refine SpA classification and treatment strategies, particularly for children.
- Addressing unmet needs in pediatric SpA is essential for improving long-term patient outcomes.
Keywords:
Axial spondyloarthritisEnthesitis-related arthritisHLA-B27Juvenile psoriatic arthritisJuvenile spondyloarthritisMore Related Videos
Related Concept Videos
01:23Degenerative Disc Disease ll: Pathophysiology
36
The symptoms of degenerative disc disease arise from a combination of mechanical compression, vascular compromise, and biochemical inflammation, which together disrupt nerve function and produce pain.Mechanical CompressionDisc degeneration reduces height and elasticity, predisposing to herniation of the nucleus pulposus, a major cause of radicular pain. Herniations may be protrusion (bulging with intact annulus), extrusion (nucleus extends beyond disc but remains connected), or sequestration...
36
01:27Degenerative Disc Disease I: Introduction
29
Degenerative disc disease is a chronic condition in which intervertebral discs gradually lose structure and function. It is not infectious or autoimmune; rather, it results from age-related biochemical and mechanical changes, influenced by genetic, metabolic, and environmental factors.Structure and Function of DiscsThe spine contains 23 intervertebral discs that absorb load, distribute forces, maintain spacing, and allow flexibility. Each disc consists of a nucleus pulposus, a gel-like core...
29
01:29Bone Disorders
8.0K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
8.0K
01:22Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies
1.3K
The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
1.3K
01:21Rheumatic Heart Disease III: Medical Management
548
Rheumatic heart disease (RHD) management can be divided into two main strategies: prevention and long-term management.Primary PreventionPrimary prevention focuses on timely diagnosis and management of group A streptococcal pharyngitis to prevent acute rheumatic fever. The most widely used antibiotic for treating this condition is intramuscular benzathine penicillin G.Acute Rheumatic Fever TreatmentThe primary treatment goal for a patient diagnosed with acute rheumatic fever is to suppress the...
548
01:25Inflammatory Bowel Disease III: Crohn's Disease
75
Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...
75