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The period of muscle contraction primarily influences the duration of stimulation at the neuromuscular junction (NMJ), the presence of free calcium ions in the sarcoplasm, and the availability of energy or ATP to support contractions.
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Updated: May 6, 2026

Axon Stretch Growth: The Mechanotransduction of Neuronal Growth
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[Biological changes after axonal stretch and their mechanisms].

Hong-ping Hou1, Li-hai Zhang, Li-cheng Zhang

  • 1Department of Orthopaedics, Chinese PLA General Hospital, Beijing 100853, China; Medical College, Nankai University, Tianjin 300071, China.

Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae
|November 5, 2013
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Summary

Peripheral nerve injuries, particularly stretch injuries, require better treatments. This review covers recent advances in understanding axonal changes after stretch, aiding pain relief and clinical effectiveness.

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Area of Science:

  • Neuroscience
  • Biomedical Engineering
  • Cell Biology

Context:

  • Peripheral nerve injuries are a significant clinical challenge.
  • Stretch injuries to peripheral nerves are common and debilitating.
  • Understanding axonal responses to stretch is crucial for developing effective treatments.

Purpose:

  • To review recent advances in the study of axonal stretch injuries.
  • To consolidate knowledge on the biological and mechanical changes occurring in axons post-stretch.
  • To provide a foundation for future research and therapeutic development.

Summary:

  • This review details morphological alterations in axons following stretch injury.
  • It examines changes in the axonal cytoskeleton, cellular membrane, and metabolism.
  • The impact of stretch on action potential propagation is also discussed.

Impact:

  • Improved understanding of stretch neuropathy mechanisms.
  • Potential for enhanced clinical strategies to treat peripheral nerve injuries.
  • Foundation for developing novel regenerative therapies for nerve damage.