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Updated: May 6, 2026

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[Drug therapy of bladder dysfunction].

R Caremel1, J-N Cornu, J Kerdraon

  • 1Service d'urologie, pavillon Derocque, CHU Charles-Nicolle, 76031 Rouen cedex, France.

Progres En Urologie : Journal De L'Association Francaise D'Urologie Et De La Societe Francaise D'Urologie
|November 5, 2013
PubMed
Summary
This summary is machine-generated.

New drugs offer more options for overactive bladder (OAB) and non-neurogenic detrusor overactivity (NDO). While anticholinergics remain first-line, new agents like beta-3 adrenergics show promise, requiring further safety evaluation.

Keywords:
AnticholinergicAnticholinergiquesBeta-3 adrenergicBladder pain syndromeBotulinum toxinBêta-3 agonistesIncontinence urinaireInhibiteur des phosphodiestérasesNeurogenic detrusor overactivityOveractive bladderSyndrome clinique d’hyperactivité vésicaleSyndrome de la douleur vésicaleToxine botuliniqueUrinary incontinence

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Area of Science:

  • Urology
  • Pharmacology

Context:

  • Bladder dysfunctions, including overactive bladder (OAB), non-neurogenic detrusor overactivity (NDO), and bladder pain syndrome, significantly impact quality of life.
  • Current treatment options for these conditions are diverse but often have limitations in efficacy or side effect profiles.

Purpose:

  • To review and describe pharmacological agents targeting the urinary bladder for the treatment of OAB, NDO, and bladder pain syndrome.
  • To evaluate the efficacy, mechanism of action, and side effects of these therapeutic molecules.

Summary:

  • Anticholinergics and antimuscarinics are established first-line treatments for OAB and NDO.
  • Beta-3 adrenergics represent a novel therapeutic class for OAB, with ongoing evaluation for safety and combination therapies.
  • Phosphodiesterase 5 inhibitors show efficacy for BPH-related lower urinary tract symptoms (LUTS), and botulinum toxin type A is approved for NDO in specific patient groups.
  • Current drug therapies for bladder pain syndrome have limited efficacy, and no treatments exist to improve bladder contractility.

Impact:

  • The expanding armamentarium for bladder dysfunction offers new therapeutic avenues.
  • Emerging drug classes necessitate careful post-approval safety monitoring and investigation into drug combinations.
  • These findings are expected to inform and potentially alter current treatment algorithms for bladder dysfunctions.