Related Experiment Video
Updated: May 6, 2026
03:26
Detrusor Underactivity Model in Rats by Conus Medullaris Transection
Published on: August 28, 2020
1.5K
Progressive vascular damage may lead to bladder underactivity in rats
Masanori Nomiya1, Osamu Yamaguchi2, Hidenori Akaihata1
1Department of Urology, Fukushima Medical University of School of Medicine, Fukushima City, Japan.
The Journal of Urology
|November 5, 2013
Summary
Progressive vascular damage in rats led to bladder underactivity. Combined arterial injury and vascular dysfunction worsened bladder dysfunction and reduced bladder muscle contractions.
Area of Science:
- Urology
- Vascular Biology
- Physiology
Background:
- Vascular damage can affect organ function.
- Bladder underactivity is a clinical concern.
Purpose of the Study:
- To investigate if progressive vascular damage causes bladder underactivity in rats.
- To assess the impact of arterial injury and endothelial dysfunction on bladder function.
Main Methods:
- Adult male Sprague Dawley rats were divided into control, L-NAME, arterial injury, and combined injury/L-NAME groups.
- Vascular damage was induced via a high-cholesterol diet, L-NAME administration, or balloon endothelial injury.
- Urodynamic studies, pharmacological assessments, and histological examinations were performed after 8 weeks.
Main Results:
- Arterial injury groups exhibited neointimal formation and luminal occlusion.
- Bladder capacity and voided volume decreased in L-NAME and injury groups but increased in the injury/L-NAME group.
- Bladder muscle contractile responses were significantly reduced in all experimental groups, most notably in the injury/L-NAME group.
Conclusions:
- Pelvic arterial occlusive disease combined with vascular endothelial dysfunction can lead to progressive vascular damage.
- This damage results in bladder dysfunction, progressing from hyperactivity to underactivity.
- The findings suggest a link between vascular health and bladder function.
