Endrin induced alterations in bound carbohydrates in rat serum

Endrin (1 mg per kg body weight) was daily administered intraperitoneally to rats which were sacrificed in groups of 10 after 5, 12 and 19 days and analyses of blood serums were conpared to appropriate controls. No alterations were found in the concentrations of general serum protein or paper electrophoretically separated serum lipoproteins, albumin, alpha1, alpha2, beta or gamma globulins. Protein bound sialic acid and methyl pentose had increased by the 5th day, remained elevated through the 12th day and appeared to be decreasing back toward control values by the 19th day although these values were still above normal. Bound hexose demonstrated no changes for the first 12 days but had increased significantly by 19 days. Bound hexosamine was significantly decreased by the end of 5 days and remained at this depressed level for the 19 days.